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Selected publications:Rodica TALMACI, PhD
Hematology Department – “Fundeni” Clinical Institute University of Medicine and Pharmacy “Carol Davila”
BIRTH DATE and PLACE: 1973 September 9th, Chisinau, Moldova
AREA OF INTEREST:
Management of development and research activity in Molecular Biology
Molecular investigation of haematological malignancies Molecular diagnosis of genetic diseases Methodology in identification of gene mutations
Ph.D. in Biology Science, major in Molecular Genetics, University of Bucharest. Ph.D. thesis title “Identification and characterization of molecular genetic basis of thalassemia in Romania”. This is the first study on mutation spectrum of thalassemia and the first implementation of molecular diagnosis and prenatal diagnosos of thalasemia in Romania. Master of Science in Compared Biology of Normal and Tumoral Cell, major in Oncobiology, University of Bucharest. Thesis title “Cytogenetic aspects in Acute Myeloid Leukemia”. Bachelor of Science in Biology, major in Cell Biology and Genetics, University of Bucharest (1990-1995). Degree thesis “The effect of influenza virus on human chromosomes in in vitro and in vivo infections”.
Other professional qualifications:
Presentation Skills Training - Educational workshop on delivering
disease area and product non-promotional messages. Delivering impact presentations training, Bucharest, Romania, 2011 LightCycler 480 Application Training at Roche Diagnostics Center, The 20th Course in Medical Genetics at European Scool of Medical Postgraduate course in Molecular Medicine, at Cellular and Molecular Medicine Department, University of Medicine and Pharmacy “Carol Davila”, Bucharest, 2007 Postdoctoral Fellowship in Molecular Diagnosis and MRD Monitoring of CML patients, at IIIrd Medical Clinic Mannheim, University of Heidelberg, Germany, 2007 Summer school “BIOGENERO-Functional Genomics in Cancer Biology and Therapy” at Department of Experimental Pathology and Molecular Biology, Cancer Institute “Ion Chiricuta” Cluj-Napoca, Romania, 2006; Research Training in Molecular Diagnosis of Thalassemias at Medical Genetics Department, First Department of Pediatrics, Athens University, St. Sophia’s Children Hospital, Athens, Greece, 2002; Postgraduate course "Actualities in Medical Genetics", at the Genetics Department, Institute of Forensic Medicine, Bucharest, 1999; Training in Human Molecular Genetics at Genetics Institute of Academy of Science from Republic of Moldova, Kishinew, 1998. EMPLOYMENT:
Lecturer and Molecular Biology Lab Coordinator at University of Medicine and Pharmacy «Carol Davila», Hematology Department - Fundeni Clinical Institute, Bucharest. In 2007 I set up and organised Molecular Biology Laboratory at “Fundeni” Hematology Department. 1996 -2006 Scientific Researcher at Genetics Institute of Bucharest University. In 1997 I organised Thalassemia Research Laboratory at Human Genetics Department.
ENEST 1st - Evaluating Nilotinib Efficacy and Safety in Clinical Trials
(2010-2012). My lab participates as National Reference EUTOS Laboratory for CML Molecular Monitoring in Romania. Research Project EUTOS for CML (European Treatment and Outcome Study for CML, lanced in July 2007 by European LeukemiaNet and NOVARTIS alliance). In this project I obtained the validation for my lab as National Reference Laboratory for CML Monitoring. The lab was involved also in 1st control round for harmonized testing of BCR-ABL mutations in CML patients Framework Package 6: European LeukemiaNet – WP4 (CML) (2004- Molecular characterization of mutations in the Coagulation Factor V gene in population with thrombiphilic risk: genotype-phenotype correlations. (National Research Programme II, 42-099 project, 2008-2011) – project supervisor. The complex study regarding characterization of genetic determinants for genotype-phenotaype correlation in thalassemia intermedia patients (National Reseasrch Programme II, 41-045 project, 2007-2010) – project director. Quantitative Real-Time PCR for molecular monitoring of Bcr-Abl transcripts in Chronic Myeloid Leukemia: founding a National Registry for CML patients (National Programme II, 41-087 2007-2010) – project supervisor. Study of gene expression by detection and quantification Bcr-Abl transcripts in CML using RT-PCR and Real Time PCR (CNCSIS 1308, 2007-2009) – project writer and supervisor Implementation and standardization of new methods for gene mutation and polymorphism study in thalassemic genes (CNCSIS 201, 2007-2009) – project director ITHANET – eInfrastructure for Thalassemia Research Network (FP 6, 2006-2008, P20 partner) – Romanian partner supervisor Screening and prenatal diagnosis of the beta-thalassemia - real filds in preventive medicine: founding a National Registry for surveillance of inherited disorders (VIASAN CEEX 49, 2005-2008) – project supervisor Identification and molecular characterization of mutations from the gene coding beta-globin chain at patients with beta-thalassemia in Romania (VIASAN 217, 2003-2005) – project supervisor Screening of heterozygotes and molecular diagnosis of patient with beta-thalassemia in Romania (2000-2002) – project director Investigations about the Romania's population genetic polymorphism with emphasis on the frequency of the genes involved in heredopathyes (1999-2000) – project parthner HONORS:
The main award of Romanian Society of Hematology – “for the best
collaboration with European LeukemiaNet in 2011”, October 2011, Sinaia, Romania Berend Houwen Travel Award, presented by the International Society for Laboratory Hematology for participation at XXII International Symposium on Technical Innovations in Laboratory Hematology, May 2009, Las Vegas, USA. IIIrd Award – poster session for “Molecular Diagnosis and MRD Monitoring in CML: single center results”, Scientific Session of Fundeni Clinical Institute, November 2008, Bucharest, Romania
“Involvement of Molecular Biology Lab in the medical education and research process at University of medicine and Pharmacy “Carol Davila”, Medical Education Days 2013, April 2013, Bucharest, Romania “The process of Molecular Monitoring and Standardization of Chronic Myeloid Leikemia in Romania”, Virtuosity in Diagnostics - Roche Days 2013, April 2013, Poiana Brasov, Romania "Definition and validation for molecular response in molecular monitoring process of CML patients treated with TKI”. Scientific Session of Romanian Society of Hematology, May 2012, Mamaia, Romania “The new status for definition and validation of Molecular Response in Chronic Myeloid Leukemia”. 11th Congress of Clinical and Blood Transfusion Hematology, September 2011, Sinaia, Romania “Molecular Diagnosis of thalassemia genes”. IIIrd Thalassemia National Molecular Diagnosis of Hereditary Thrombophilia. National Workshop of Romanian Society of Hemostasis and Thrombosis, 14,15 May 2010, Iasi, Romania “Molecular monitoring of patients with Chronic Myeloid Leukemia”, „Phenotype-Genotype correlation studies on thalassemia: identification of new molecular patterns in some difficult cases from Romania. Seminar: Romania & Cyprus – Information Society, a mini-guide to advance i2010. October 30-31 2008, Nicosia, Cyprus “Molecular Monitoring of patients with CML: molecular diagnosis of drug resistance” BMS Advisory Board Meeting, July 2007, Sibiu, Romania TEACHING EXPERIENCE:
Organize and host annual workshop “Clinician’s Day in the Lab” on Molecular Diagnosis and Monitoring of CML patients treated with TK inhibitors, Molecular Biology Laboratory, Hematology Department, Fundeni Clinical Institute, 2009-2013. Organize and host Thalassemia Workshop: “Thalassemia Research: finding for better diagnosis and management”, Molecular Biology Laboratory, Hematology Department, Fundeni Clinical Institute, September, 2010, Bucharest, Romania Organize and host LightCycler Workshop: “Universal ProbeLibrary, Guide to Successful qPCR Assays”, Molecular Biology Laboratory, Hematology Department, Fundeni Clinical Institute, November 2009, Bucharest, Romania Lectures and Practical Courses on Molecular Diagnosis of Haematological Diseases, for students, postgraduated students, haematologists and laboratory specialists. Supervised Master Student Activity: 6 research works on thalassemia, thrombophilia, amyloidosis, myeloproliferative disorders and leukemia. Supervised Graduate Student Activity: 10 research works on Publication List
Books (in Romanian):
1. Coriu D., Colita D., Colita A., Dobrea C., Moicean A., Niculescu-Mizil E., Talmaci R., Tatic A.,
Ursuleac I, Nicoara S. Myeloproliferative neoplasms in the molecular era. Editura Universitara “Carol Davila”, Bucharest, 2013. ISBN: 978-973-708-647-1 2. R. Talmaci. Molecular genetic basis of alpha-thalassemia. ARS Docendi, Bucharest, 2010.
3. R. Talmaci. Molecular genetic basis of beta-thalassemia. ARS Docendi, Bucharest, 2009. ISBN:
4. D. Coriu and R. Talmaci. Thalassemia syndromes. Ed. Universitara “Carol Davila”, Bucharest,
Chapters in books (in Romanian):
1. Moise B., Beladan C., Uscatescu V., Talmaci R., Coriu D., Nichita E., Ginghina C. “Massive
Pulmonary Embolism-how many risc factors are needed?” (in:) Imagistics in cardiac patients, vol. VI. Edited by Carmen Ginghina, Ed. Editura Medicala, 2012. ISBN: 978-973-39-0735-0 2. Coriu D., Colita D., Talmaci R., Cherry L., Dan L. Gavrila L. “Genetics of erythropoiesis and
immune mechanisms in human blood system”. (in:) Immunogenetics and oncogenetics. Part I. Edited by Gavrila L. & Ardelean A., Ed. Romanian Academy, Bucuresti, 2009. ISBN: 978-973-27-1848-3 3. Rodica Talmaci “Gene mapping strategies”, “Genome organization in mammalians”, “Human
genome analysis”, “Human genome in pathology” chapters in Genomics I and Genomics II, Ed. Enciclopedica Bucharest, 2003. ISBN: 973-45-0463-0 and ISBN: 973-45-0465-7 4. Rodica Talmaci “Gene mapping”, “Mutations in human mitochondrial genome. Human
mitochondrial diseases”, “Gene therapy in mitochondrial diseases” “Human mitochondrial genome” chapters in Extranuclear heredity, Ed. of Bucharest University, 2000. ISBN: 973-575-414-2. Original articles published in scientific journals:
1. Dumitru Jardan, Rodica Talmaci, Cerasela Jardan, Daniel Coriu, Anca Colita,
Andrei Colita, Constantin Arion. Real-time qPCR for assessment of minimal residual disease in acute myeloid and lymphoid leukemia. Revista Romana de Medicina de Laborator, nr. 4 / 2011. 2. Kinga Tatar, Rodica Talmaci, Dumitru Jardan, Maria Damian, Adriana Coliță,
Hortensia Ioniță, Coriu Daniel. Identification of second generation tyrosine kinase inhibitors relevant mutations in a cohort of chronic myeloid leukemia patients treated in a single center in Romania. Revista Romana de Medicina de Laborator, nr. 4 / 2011. 3. Dogaru M., Talmaci R., Coriu D., Badelita S. Sensitivity, specificity and
efficiency of different discriminative indexes in differentiation of thalassemia trait from iron deciciency anemia. Biointerface research in applied chemistry, 2011, Vol.1, no 1, pp 2-8 4. Vladareanu AM., Voican I., Bumbea H., Vasile D., Radesi S., Coriu D., Colita A., Talmaci R., Ilea A. Chronic Myeloid Leukemia – From the National to the
European Registry – Limited Experience of a Single Center. Romanian J. Intern Med, 2010, 48 (1): 73-79 5. Talmaci R, Coriu D, Dan L, Cherry L, Gavrila L, Barbarii L, Dogaru M,
Vladareanu F, Vladareanu R, Peltecu G, Colita D. Prenatal molecular diagnosis of -thalassemia: report on the first two cases in Romania. Journal of Medicine and Life, 2008, 1 (2): 138-147 6. Dan L, Talmaci R, Cherry L, Coriu D, Cimponeriu D, Usurelu D, Apostol P,
Gavrila L. DGGE - hunting for point mutations în β-globin gene of β-thalassemia patients. Romanian Journal of Genetics, 2005, 1 (2): 75-80 7. Rodica Talmaci, Traeger-Synodinos J., Kanavakis E., Coriu D., Colita D,
Gavrila L. Scanning of -globin gene for -thalassemia mutation identification in
Romanian population. Journal of Cellular and Molecular Medicine, 2004, 8
8. Talmaci R., Gavrila L. Detection of β-thalassemia alleles by the ARMS-PCR
method in Romania. Romanian Biotechnological Letters 2003, 8 (3): 1241-1246 9. Talmaci R., L. Gavrila. Application of Molecular Diagnosis Technologies in Beta-
Thalassemia: Enzymatically Amplified DNA and Restriction Site Analysis, Roumanian Biotechnological Letters – an international journal, 2001, 6 (1) : 63-70 10. Gavrila L., M. Marinescu, L. Ghetea, M. Stefan, A. Petrescu, R. Talmaci, L. B.
Gavrila, V. R. Gavrila. Cytogenetical studies of miners from uranium mines in the Western Carpathians, Cytology, Tokyo, 1997, 62:369-376 11. Dumitrescu M, Gavrila V.R., Gavrila L.B., Ghetea L., Grecu C., Alexandru G., Talmaci R., Stefan M., Petrescu A., Mihaescu G., Scorpan V., Bujorean V.,
Jacota A., Bucur E., Pascale F., Vior C., Gavrila L. Biochemical and
cytogenetical study of the mycoplasmal antigen and of the cyclophosphamide
action in mammals, in vivo. The action of some immunomodulatory antioxidants,
Roum. Arch. Microbiol. Imunibiol., 1996, 55 (3): 225–239
1. Coriu D., Talmaci R. Thalassemia Syndromes. Documenta Haematologica
2. Rodica Talmaci. Molecular diagnosis of beta-thalassemias. Progress in
Biotechnology, vol. II. Ed. Ars Docendi 2002, 179-188 3. Rodica Talmaci and Lucian Gavrila. Gene amplification aspects in human
pathology. Progress in Biotechnology, 2001, 304-313
Over 60 work titles presented as Abstracts, Poster Presentations and Talks at
national and international professional events.
Sei in der medizinischen Forschung die Grundgesamtheit der M¨ur einen Herzinfarkt indentifiziert. Aus Erfahrungsberichten von Pa-tienten werde vermutet, dass die regelm¨aßige Einnahme einer geringen Menge Aspirin das Risikoeines Herzinfarktes senken kann. Sie seien Teil einer Forschergruppe, die diese Hypthese untersuchenochte, und beraten diese auf statistischem Gebiet. Ihre Kollegen aus