Le sildénafil présent dans Kamagra exerce une inhibition réversible de la PDE5, modulant la cascade GMPc et favorisant une vasodilatation localisée. L’absorption digestive varie selon la forme utilisée, comprimés classiques ou gels oraux. La distribution tissulaire est large et la liaison protéique élevée, avoisinant 96 %. La métabolisation hépatique génère un métabolite actif contribuant à l’effet pharmacologique global. La demi-vie reste courte, avec disparition plasmatique en quelques heures. Les interactions significatives concernent surtout les nitrés organiques et inhibiteurs puissants du CYP3A4. Dans les publications techniques, kamagra en ligne est souvent cité dans le cadre d’analyses comparatives portant sur les différences de formulations et de cinétique d’absorption.

Treatment of scabies with albendazole

Letter to Dermatology
Benzimidazoles (albendazole, fenbendazole, oxfenbendazole, mebendazole, thiabendazole) are broad antiparasitic agents used Treatment of Scabies with Albendazole
against a wide range of nematodes and cestodes. By binding to free ␤ -tubulin, benzimidazoles inhibit the polymerization of tu- bulin and the microtubule-dependant glucose uptake, leading to Université Saint-Joseph, Hôtel-Dieu de France, Beirut , Lebanon parasitic death. These agents may additionally interfere with the synaptic transmission of parasites through a probable cholinergic effect [2] . Effectiveness of oral and topical thiabendazole against scabies has been pointed out in few reports since the 1960s [3, 4], and thiabendazole and the newer agent albendazole have been successfully used against pediculosis capitis [2, 5] ; yet little atten- Scabies is a highly communicable disease caused by infesta- tion has been paid to the antiscabies properties of benzimidazoles, tion with Sarcoptes scabiei var. hominis . Current treatments for given the limited experience with these drugs in this setting. Our scabies include benzyl benzoate, malathion, lindane and perme- observations represent, to our knowledge, the first cases of scabies thrin in addition to ivermectin [1] . The latter represents the only successfully treated with oral albendazole and suggest that this approved oral treatment for scabies and the therapeutic option for agent provides a potential therapeutic option for scabies. Further community-based treatment. Scabies outbreaks remain a serious evaluation of the effectiveness of albendazole against scabies is public health issue in Lebanon, and the failures of topical treat- ment modalities prove challenging to manage, given the unavail-ability of ivermectin in our country. We report 2 patients with scabies who were successfully treated with oral albendazole.
1 Chosidow O: Clinical practises. Scabies. N Engl J Med 2006; 354: 1718– 2 Namazi MR: Treatment of pediculosis capitis with thiabendazole: a Case 1. A 63-year-old woman presented clinical evidence of pilot study. Int J Dermatol 2003; 42: 973–976. 3 Hernandez-Perez E: Topically applied thiabendazole in the treatment crusted scabies. Diagnosis was ascertained by skin scrapings pos- of scabies. Arch Dermatol 1976; 112: 1400–1401. itive for S. scabiei . Several head-to-toe applications of benzyl ben- 4 Allegre T, Cailleres S, Lota I, et al: Value of thiabendazole in scabies zoate and lindane had been ineffective 2 months earlier. The pa- resistant to local treatment in HIV infected patients. Presse Med 1992; tient was prescribed a daily dose of 1,000 mg of albendazole with fatty meals for 3 consecutive days and an application of a 5% sal- 5 Akisu C, Delibas SB, Aksoy U: Albendazole: single or combination icylic acid ointment once daily for 1 week. The pruritus disap- therapy with permethrin against pediculosis capitis. Pediatr Dermatol peared within 5 days. Skin scrapings performed at the 1-week con- trol visit on residual skin lesions did not reveal any Sarcoptes mites. Lesions disappeared completely within 10 days. No side ef- fects or recurrence were observed during 3 months of follow-up.
Université Saint-Joseph , Hôtel-Dieu de France Case 2. A 76-year-old man with Alzheimer’s disease who had PO Box 16 - 6830, Achrafieh, Beirut (Lebanon) previously been treated with topical benzyl benzoate and per- Tel. +961 3 664 604, Fax +961 1 616 160, E-Mail rtomb@usj.edu.lb methrin had extensive scabies. Skin scraping revealed live Sarcop-tes . The patient was administered 3 daily doses of 1,000 mg of albendazole along with fatty meals. Skin lesions disappeared within 1 week. No recurrence was observed during the 2 months of follow-up.
Fax +41 61 306 12 34E-Mail karger@karger.ch

Source: http://www.rolandtomb.info/pdf/Scabies.pdf