CHML TREATMENT Overview This is a clinical study to evaluate efficacy of Cytotroic Heterogenous Molecular Lipids (CHML), in patients with advanced or metastatic disease. Response to treatment, duration of response, and survival will be followed. Patients are treated with 7 mg/kg of CHML, one time per day, 5 to 7 days per week by Intravenous drip (IV), Arterial infusion, local inject
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Ben's notesBen’s Suggested load out
FOR YOUR VEHICLE (MINI-VAN RECOMMENDED):
n Flashlight(s): regular and mini-mag light n Ice chests (2): and large fluid container (Igloo) n Folding chair(s) with cot (with pad) n Trash bags and/or trash barrel; broom for U-Haul n Zip-lock bags; chip clips n Cutting board and utensils, plates, cups, etc. n Bucket or basin (for feet, etc.) n Scale for weighing during race; don't use digital read-out kind (hard to read in bright n Electric coffee pot or hot plate or toaster/oven for heating water, cooking, etc. n Extension cord and a variety of electrical adapters (two-to-three-way, socket type, etc.) n Small microwave oven (optional but very helpful at Stovepipe and Panamint) n Clip board, pens, pencils, note paper, etc. (to keep track of your adventure, n Rope, cord, string, etc. n Towels (including beach towel) and rags n Soap (dish soap), sponges and scouring pads n Bug spray n Step for getting in and out of vehicle (or for just using as a chair) n Porta Potti and toilet paper n Camera(s) and film n Cellular phone (optional but very popular) n GPS (global position system)(for techo-nerds only) n Crisp $1.00 bills for vending machines including ice machine n Maps: Inyo County; Death Valley; Owens Valley; Whitney Area (topo) FOOD AND DRINKS:
n Water: bottled; Crystal Geyser usually donates 2 cases per runner Gatorade, Cytomax, Exceed, Club Soda, etc. Pretzels, peanuts, corn-nuts, rock salt, etc. Gum drops, jelly beans, fig newtons, pop tarts. etc. n Watermelon, cantaloupe and other fruit (oragnes) Dark bread, sliced turkey, jack cheese, peanut butter, jelly, etc., for sandwiches MEDICINES:
n Sun block, chap stick, zinc oxide, etc. n Thermometer for body temperature and outside air temperature n Diamox 250 mg tablets for high altitude sickness prevention (suggested-see M.D.). n Water purification tablets or water filter for Giardia on Whitney trail FOOT BOX:
n Micropore tape (3M), Band-Aids, dressings, etc. n Compeed, Elastogel, Duoderm, etc., for pressure areas and blisters n Swabs, needles, razor blades, tweezers, scissors, etc. n Nylon stockings, ankle length, to go over skin before socks to help prevent chaffing and RUNNING GEAR:
n Full coverage solar gear (Sun Precautions) n Singlet with logos for the media, advertising, self-pormotion, running for charity, etc. n Running shoes (several pairs) and maybe one size larger than ordinary (use white or n Inner soles; Soft Soles work well for us for cushioning and insulation n Orthotics, etc. n Socks; double thickness work well; consider Supphose for swelling) n Hat with long-bill or wide brim plus shroud n Dark glasses (two layers, one which flips up or down) n Summit goggles and or shields for side-stems (for side-glare) n Consider nose shield which fits on glasses n Goggles (swimming type) for sand storms n Reflective gear, strobe light, flashers, etc., for night time n Fanny pack with water bottles MOUNTAIN GEAR:
n Polypropolene inner-layer top and bottom n Gore-Tex outer-layer top and bottom n Gloves CHECK WITH MOUNTAINEER/GUIDE REGARDING THE FOLLOWING:
n Ski poles; longest and rigid are the best; or telescopic n Crampons for ice; consider in-step crampons (optional) n Rope if snow and ice conditions dictate n Ice ax (need to know how to use this; can be dangerous) Crew Assignments
Crewing Tips for the Badwater Ultramarathon
Due to the unique nature of the Badwater Race, we thought it might be helpful to make some suggestions
with the hopes that they might insure a successful experience for both the competitors and their crew
members. As most of you know, the crew is essential to the competitor completing this event; and in fact, is
a requirement by the race officials. Crewing for this race can be as taxing as competing (we've done both).
Thus, we share some ideas that have helped us during the event in the past.
You can expect:
• EXTREME EXHAUSTION • EXTREME FRUSTRATION at times • EXTREME JOY.when it's over!!!!! 1. The crew needs to familiarize themselves with the crew vehicle and it's organization. It would be advantageous for the athlete to be involved in setting the crew vehicle up so it can be arranged in a manner that makes logical sense to everyone that will be working out of it. Keeping the crew vehicle clean and organized helps everyone, too. Putting things back where you found them makes it easier for the next person on shift. 2. If there are only two crew members, it needs to be decided when rest breaks will take place so that at least one crew member is rested. If there are more than two, it's a bit easier to take rest breaks. During the rest, try to rest or sleep. A tired crew is no help to the athlete. We get motel rooms for our crew, but I know it's not always possible due to s ome budgets. If at least one crew member is mentally sharp and fairly well rested, it makes the entire experience run more smoothly. By the time the competitor is tired, decisions are harder. If everyone is tired, it's much harder to keep the competitor mo ving. 3. Hopefully the crew will be familiar with blister treatment. If not, please try to get some help before the race starts with someone that has treated blisters. Often, it seems, even when most athletes don't have blister problems, they tend to blister in this race due to the excessive heat of the pavement. Try to have a blister kit organized specifically for this issue. It's been a life-saver for most competitors. 4. It has been our experience that if a water sprayer is used for cooling down the athlete, that avoiding the legs is helpful. It seems that when the water runs down the legs, feet blister more, and can cause chafing of the thighs. One competitor had to drop out a couple of years ago due to the crew not knowing this. Sometimes athletes like their legs cooled, but be sure to check first before letting loose with the sprayer. Don't be surprised if your athlete gets heat rash on legs.I've had it twice in this event. It goes away and Desetin ointment helps! 5. Crews need to be aware that they HAVE to drink fluids to prevent dehydration. not just the athlete. We've seen a lot of sick crew from not watching out for their own welfare while in the throws of crewing. It's easy to get distracted and forget to drink.! Iced fluids seem to keep the body t emperature down better. We ice everything. 6. Sunscreen and sun protective clothing is helpful for crewing. Sunburned crew aren't happy crew. Hats are essential. The hazards of sunburn, dehydration, sun stroke are very real for the crew as well as the athlete. Beware of how quickly this can happen. It can happen in as little as 15 minutes. 7. Hopefully, crew members will co-operate with each other to make the whole experience a memorable one. Communicate with the athlete, and with each other as crew members. Watch your athlete's moods and behavior. Low moods are expected at times, but sometimes can indicate low blood sugar. It's as simple as giving something with sugar in it to help. 8. If you encounter problems with your vehicle or your athlete, please let the race staff know. Their officials skirt the course. Ben will be doing the same thing, to see how everyone is doing. Just let him know and he'll notify the race director. The sooner a problem is addressed, the soon is can be resolved. We've even encountered flat tires out there. The U-Haul company sent mechanics out on the course (from Ridgecrest) to fix our tire while we continued in the race (of course we had dual wheels). 9. Watch out for the traffic. Be careful crossing the road on foot, if you are helping your athlete. Make sure your crew vehicle is off the pavement so you won't get a ticket. The Badwater Ultramarathon is a unique event. It is.EXTREME! Please understand that by your crewing
you are helping your athlete complete a very important goal. Good crew attitudes along with good manners
and organization can make this am amazing and thrilling experience for everyone. You will enjoy a great
sense of achievement to have joined your athlete in this event. We truly believe that no o ne that participates
in this event leaves it the same. It will be a very memorable life experience, and we know your athlete will
be grateful to you for your help forever! And, last but not least, we are hoping that everyone has a
memorable, enjoyable and successful race in 2001!
Getting Water and Ice
Runners and crews must come fully prepared for this event. Many buy all their supplies in Las Vegas or
Los Angeles, depending on which airport they are using. It is important to keep in mind that services are
available infrequently along the route. Ice and water, and other supplies, is usually available at the
following locations during working hours:
Furnace Creek (gas, water, ice, market, restaurant, hotel, camping)
Stove Pipe Wells (gas, water, ice, market, restaurant, hotel, camping)
Panamint Springs Resort (water, ice, restaurant, hotel, camping)
Lone Pine (all services)
Pace Chart for Finish Times from Badwater to Whitney Portal
Hours mph min/mile 24 5.62 10:40 25 5.40 11:07 26 5.19 11:33 26:18:00 5.14 11:41 (a) 27 5.00 12:00 28 4.82 12:26 29 4.65 12:53 29:10:00 4.63 12:58 (b) 30 4.50 13:20 31 4.35 13:46 32 4.21 14:13 33 4.09 14:40 34 3.97 15:07 35 3.85 15:33 36 3.75 16:00 36:19:20 3.71 16:08 (c) 37 3.64 16:26 37:01:00 3.64 16:27 (d) 38 3.55 16:53 39 3.46 17:20 40 3.37 17:46 41 3.29 18:13 42 3.21 18:40 43 3.13 19:07 44 3.06 19:33 45 3.00 20:00 46 2.93 20:26 47 2.87 20:53 48 2.81 21:20 49 2.75 21:46 50 2.70 22:13 51 2.64 22:40 52 2.59 23:07 53 2.54 23:33 54 2.50 24:00 55 2.45 24:26 56 2.41 24:53 57 2.36 25:20 58 2.32 25:46 59 2.28 26:13 60 2.25 26:40 (a) Marshall Ulrich's PM (1800) record (b) David Jones' AM (0600) record (c) Bonnie Boyer's PM (1800) record (d) Lisa Smith's AM (0600) record
POTENTIAL TREATMENTS FOR CREUTZFELDT-JAKOB DISEASE (& OTHER HUMAN PRION DISEASES) Professor RSG Knight, NCJDRSU updated August 2012 Creutzfeldt-Jakob disease and other human prion diseases are invariably progressive and fatal; there is currently no proven treatment for the underlying disease process. The identification of possible treatments can be based on theoretical co