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Chml treatment (for patients)CHML TREATMENT
This is a clinical study to evaluate efficacy of Cytotroic Heterogenous Molecular Lipids
(CHML), in patients with advanced or metastatic disease. Response to treatment,
duration of response, and survival will be followed.
Patients are treated with 7 mg/kg of CHML, one time per day, 5 to 7 days per week by
Intravenous drip (IV), Arterial infusion, local injection, or a combination of these
Treatment will continue for 2 weeks, followed by 2 to 4 weeks off, for a total of 2 to 3
Histologically confirmed diagnosis or biopsy for carcinoma, myeloma; melanoma,
sarcoma; melanocarcinoma, lymphoma; or, solid tumor(s) including the following sites:
breast, prostate, pancreas, colon, rectum, lung, stomach, liver.
Measurable tumor size by X-ray, CT, MRI, or ultrasonography Performance status / scale: ECOG 0 – 2. (Karnofsky: > 60) Estimation for survival time: >3 months Function of major organs (e.g. heart, lung, liver, kidney, stomach, colon and bone marrow) within normal range (according to World Health Organization guidelines)
Primary, recurrent or metastatic cancer, including lymphoma and leukemia.
Special Requirements for Breast Cancer
Urgent local complications resolved prior to entry (e.g. untreated hypdronephrosis, impending spinal cord compressions) Severe bone pain unresponsive to analgesics Liver tumor replacement less than 50% total liver surface
Special Requirements for Prostate Cancer
Leuprolide continued in non-orchiectomized patients. At least 4 weeks since PSA at least 20 ng/mL (if no measurable or evaluable disease)
Biological Therapy: Not specified.
At least 4 weeks since last treatment (6 weeks since nitrosoureas or mitomycin) are recovered. Endocrine Therapy: The use of corticosteroids is permitted, if necessary, however it is recommended that the smallest dose be used and recorded. No prior radiotherapy to more than 40% of bone marrow. At least 4 weeks since radiotherapy and recovered. At least 6 weeks since bone-seeking radioisotopes.
Hematopoietic: Absolute granulocyte count greater than 1,500/mm
Hemoglobin less than or equal to 6.5 mg/dl SGPT and SGOT less than 5 times upper limit of normal concentration in serum not higher than 2.5 mg/ml Cretonne clearance (measured) at least 50 mL Significant arrhythmias (e.g. greater than first-degree heart No unstable or newly diagnosed angina pectoris Less than fully compensated congestive cardiac failure No myocardial infarction within 6 months No class II-IV congestive heart failure Uncontrolled and symptomatic atrial dysrhythmia, EXCEPT sinus, bradycardia or sustained ventricular tachycardia Forced vital capacity at least 1,000 mL No major uncontrolled active infection (unless due to obstructed bronchus) Patients with severe allergic reactions to iodine contrast which can not be controlled by premedication with antihistamines and steroids are not eligible, as hepatic angiograms are required for this procedure. No active infection requiring antibiotics within 7 days prior to No patients with known chronic heart failure and serious lung Patients must be aware of the neoplastic nature of his/her illness, the experimental nature of the therapy, alternative treatments, potential benefits, and risks. Patients must not have a history of veno occlusive disease o Percutaneous nephrostomy tube, Ileal pouch, Indwelling No peripheral neuropathy greater than grade II Patients with hypertension are excluded (unless blood pressure No requirement for therapeutic warfarin or heparin No history of uncontrolled seizures within 1 year and no Not pregnant or nursing (negative beta-HCG required for Patient must be willing to sign an informed consent Effective contraception required for fertile patients during and No history of diabetes mellitus within 6 months of enrollment No patients with high medical or psychiatric risk, or non- malignant systemic disease which would, in the opinion of the investigator, make therapy with an investigational drug unwise Female patients must not be pregnant or breast-feeding an infant, and either incapable of becoming pregnant or currently using contraceptive methods. Male patients should use appropriate contraception during the study, and for at least 4 weeks post treatment Special Instruction
Many protocols may be potentially hazardous and are intended only for use by clinical
specialists in carefully structured settings, and may not prove to be more effective than
standard treatment. Dose and schedule modifications may be required for patients who
develop gastrointestinal, hematologic, neurologic, and biochemical (renal, hepatic, etc.)
and/or other abnormalities and the administration of therapy.
THIS MEETING WAS QUORATE Milton Keynes, Oxfordshire, Berkshire East, Berkshire West & Buckinghamshire (MOBB) Priorities Committee Minutes of meeting held on Wednesday 25 January 2012, Jubilee House, Oxford Business Park South, Oxford, OX4 2LH Present: Committee Members Head of Medicines Management, NHS Bucks Associate Medical Director, Bucks Hosp NHS Trust