Microsoft powerpoint - dementia_symposium
Postoperative Delirium &
Cognitive Decline
Delirium & POCD
DELIRIUM vs. POCD
Wang et al., Am J Geriatr Psychiatry 2007;15:50
Incidence of Delirium J Am Geriatr Soc
Population
Incidence
Hip fracture
Berggren et al.
Edlund et al.
Morrison et al.
Schuurman et al.
Elective orthopedic
Fisher et al.
Rogers et al.
Elective Liver resection
Yoshimura et al.
Major elective surgery
9% (46% aortic
Marcantonio et al.
surgery)
Elective vascular
36% (52% aortic)
Schneider et a.
Delirium Risk Factors
Delirium is a multifactorial syndrome influenced
by:
Baseline patient risk factors (vulnerability)
Precipitating factors
Patients with more baseline risk factors and
exposed to more precipitating factors are much
more likely to develop delirium
Potential surgical risk factors
• Blood loss
(Marcantonio, Am J Med 1998)• Type of surgery
(Cardiac, orthopedic)
Potential anesthetic factors
Anesthetic factors
•
Types (general vs. regional)
•
Williams-Russo, JAMA 1995
•
Rasmussen, Acta Anaesthesiol Scand 2003
•
Management (intra- &/or post-op)
•
Williams-Russo, Anesthesiology 1999
•
Specific anesthetic agent
•
Leung et al, Br J Anaesth, 2006
Pain & postoperative delirium
• Age > 70 years• Moderate to severe preop rest pain • Increase in pain at rest preop vs. POD #1 • Oral narcotics vs. PCA
Vaurio L et al., Anesth & Analg 2006
Clinical trials in postoperative delirium
“proactive geriatric consultation” vs. standard care –
Clinical trial of gabapentin vs. placebo•
Postop delirium 5/12 in placebo vs. 0/9 in
Sedation depth during spinal anesthesia for hip
Postop delirium 19% in light sedation vs. 40% in
JAGS. 2001;49:516-22Neurology 2006; 67:1-3
Mayo Clin Proc. 2010;85:18-26
Clinical trials in postoperative delirium
Rivastigmine in elective cardiac surgery
Postop delirium 3% in dexmedetomidine, vs. 50%
each in propofol or midazolam groups, n=90
Crit Care Med. 2009;37:1762-8Psychosomatics. 2009;50:206-17
Risk factors for
early/intermediate POCD
Patient-related Risk Factor
Precipitating factors for
early/intermediate POCD
Perioperative Risk
Incidence of POCD
Risk of General anesthesia & cognitive decline
sectional study (Maastricht Aging Study,
946 patients with at least one operation
Results: a history of an operation, # of
operations, total duration of anesthesia
complaints but did not predict cognitive
Dijkstra et al., JAGS 1998;46:1258-1265
Surgery and long-term cognitive decline
Surgery and long-term cognitive decline
Avidan et al. Anesthesiology 2009;111:964-970
Surgery and long-term cognitive decline
Avidan et al. Anesthesiology 2009;111:964-970
Surgery and long-term cognitive decline
to a CDR > 0, but not more common after
cognitive decline attributable to surgery or
Avidan et al. Anesthesiology 2009;111:964-970
MCI and POCD
participating in aging studies at the NYU
expected for a person’s age, without ADL
Bekker et al. Am J Surg 2010;198:782-788
MCI and POCD
showed those with MCI had a significantly
greater decline in performance on the DS-
Bekker et al. Am J Surg 2010;198:782-788
POCD and long-term mortality/cognition
mortality at 1 yr & 3 months after surgery
Monk et al. Anesthesiology 2008;108:18-30Steinmetz et al. Anesthesiology 2009;110:548-555Newman et al. New Eng J Med 2001;344:395-402
Source: https://www.cme.ucsf.edu/2011/slides/MNR11004/09%20Leung.pdf
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