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role in the production and health of cartilage, the soft Are you one of the 38 million American adults that rubber-like padding that cushions the ends of bones and suffer from some form of joint discomfort? Has your prevents them from grinding painfully against each other joint mobility declined due to an overly active lifestyle, as the joint moves. It also helps develop ligaments, The US Center for Disease Control predicts that the number of adults suffering from joint discomforts glycosaminoglycans and proteoglycans, two vital building blocks of cartilage. Usually the joints make sufficient glucosamine to keep the cartilage in good shape, but as we age, we lose some of the glucosamine and other substances. The cartilage can dry out, deteriorate, crack, or become thin from wear. Left exposed, the joints may become inflamed, stiff, swollen, deteriorate. This can be caused by recurring joint tender and painful – a condition known as osteoarthritis stress, physical injuries, or heredity. This is usually or degenerative joint disease. (This condition is caused accompanied by agonizing pain and limited mobility.
by the breakdown of cartilage. It is characterized by The current methods for treating joint discomfort are operations, such as knee or hip replacements, Creatine Monohydrate is an amino acid compound aspirin/ibuprofen, prescription drugs, and nutritional that is stored in muscle tissue where it is used to create supplements. Three supplements that seem to provide the energy required by muscles. It is essential to muscle effective joint pain relief are Chondroitin Sulfate, contraction and helps in the muscle-building process.
Glucosamine Sulfate, and Creatine Monohydrate.
Health Benefits
Chondroitin is a complex carbohydrate found in the Chondroitin Sulfate is a powerful anti-inflammatory connective tissue of all mammals. In the cartilage that that seems to promote flexibility in tendons, ligaments, cushions the joints, chondroitin will draw fluid into the and cartilage. Glucosamine Sulfate appears to support tissues; an important property, as there is no blood the regeneration of cartilage and helps lubricate joint supplied to cartilage. This fluid draws important surfaces for easier movement. Creatine Monohydrate nutrients to the area, making the cartilage spongier and appears helpful for improving muscle strength and more capable of absorbing shocks. Chondroitin also shields healthy cartilage from early deterioration bypreventing the production of certain enzymes that Advanced Joint Formula
weaken connective tissue and overpowering other enzymes that stop nutrients from reaching the cartilage.
joint mobility and relieve the pain.
Many researchers are convinced that chondroitin can strengthen the protein strands that make up connective tissue. Some evidence has shown that, because it contains complex sugar molecules called glycosaminoglycans, it can reduce inflammation and repair cartilage, especially if the tissue has not been totally damaged. Chondroitin seems to play an active “pain buster” ingredients – Chondroitin role in reducing the pain that often accompanies joint problems. Chondroitin has also been used to treat torn ligaments and tendons because of its positive effect on Citrate and Magnesium for bone development, and 4) Lipase and Amylase to enhance the delivery of the other Glucosamine is a natural substance created by the ingredients and to help in inflammatory conditions.
body and found in certain foods. It plays an important pain by taking the combination. In contrast, only Supplement Facts
54.3% of the patients in the placebo group experienced In a double blind, four-week study conducted in China, 178 Chinese patients with knee osteoarthritis were divided into two groups. One group took a daily dose of 1500 mg of Glucosamine Sulfate and the other took 1200 mg of ibuprofen daily. The researchers monitored the level of pain for knees when they were at rest, during movement, and under pressure. The amount of swelling and mobility were also measured.
Both groups experienced a significant reduction in pain Suggested dosage: For usual adult dosage: take two
symptoms. Researchers observed from the results that capsules twice daily with meals, or as needed.
the glucosamine group tended to: 1) have greatersymptom reduction, 2) experienced the positive Scientific Studies
benefits of the treatment for a longer period after it was An article in a 2003 issue of Drugs and Aging stopped, and 3) have significantly less adverse side documents the results of seven studies designed to evaluate the efficacy of using glucosamine inosteoarthritis cases. In two such placebo-controlled References:
studies, 414 patients with osteoarthritis were monitored Matheson Anna J., Perry Carolina M. “Glucosamine: A Review during a three-year period. The patients taking of it Use in the Management of Osteoarthritis.” Drugs and glucosamine in this long-term study experienced greater Aging (20:14 pages 1041-1060). Adis International:Pennsylvania; 2003.
improvements in joint structure changes and a decreasein symptom severity compared to the placebo group.
Retzlaff Kimerly J. “Glucosamine: Arthritis pain’s natural foejust got more street credibility at the American College of In other double-blind studies where glucosamine was Rheumatology’s annual scientific meeting.” Better Nutrition.
evaluated against ibuprofen and/or an arthritis drug (piroxicam), patients taking glucosamine experienced Qiu G.X., Gao S.N., Giacovelli G., Rovati L., Setnikar I. “Efficacy relief of symptoms that were equal to or better than the and Safety of Glucosamine Sulfate versus Ibuprofen in patients in the non-glucosamine group. Further, Patients with Knee Osteoarthritis.” Arzneimittelforschung patients in the glucosamine group had much lower incidents of gastrointestinal disturbances, fatigue, and Resources:
skin problems than those taking ibuprofen or arthritisdrugs. The overall conclusion of the authors of the Clouatre Dallas, “Glucosamine Sulfate and ChondroitinSulfate.” Keats: Illinois; 1999.
article was that in the short-term clinical studies theyreviewed that glucosamine provided effective relief of Health Canada Monograph – Glucosamine.
symptoms associated with osteoarthritis of the knee.
Health Canada Monograph – Chondroitin Sulfate.
And, that glucosamine showed potential for modifying Health Canada Monograph – Calcium.
the progression of joint-related conditions.
Sahelian MD Ray, Tuttle Dave, “All About Creatine.” Avery In a study involving 1258 patients with knee joint Publishing Group: New York; 1998.
conditions conducted by the University of Utah in SaltLake City, researchers evaluated the results of five Toews Victoria Dolby, “User’s Guide to Glucosamine andChondroitin.” Basic Health Publications: California; 2002.
different treatments – glucosamine, chondroitin, amixture of glucosamine and chondroitin, an arthritisdrug (Celebrex), and a placebo. At the end of sixmonths, researchers noted that patients taking the Contact Information: R-Garden Inc., 1-800-800-1927 mixture of glucosamine and chondroitin saw the most The FDA has not evaluated these statements. This product improvement. Further, 79.2% of the patients with is not intended to diagnose, treat, cure or prevent any severe pain experienced a minimum 20% reduction in

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