Ecstatic Birth - Nature’s Hormonal Blueprint for Labour This article has been previously published in Mothering Magazine, issue 111, March-April 2002, and also in Byron Child, issue 5, March 2003. An expanded and updated version of this article is available in Sarah’s book: Gentle Birth, Gentle Mothering; The wisdom and science of gentle choices in pregnancy, birth, and parenting. Details are available at Giving birth in ecstasy: This is our birthright and our body’s intent. Mother Nature, in her wisdom, prescribes birthing hormones that take us outside (ec) our usual state (stasis), so that we can be transformed on every level as we enter motherhood. This exquisite hormonal orchestration unfolds optimally when birth is undisturbed, enhancing safety for both mother and baby. Science is also increasingly discovering what we realise as mothers - that our way of birth affects us life-long, both mother and baby, and that an ecstatic birth, a birth that takes us beyond our Self, is the gift of a life-time. Four major hormonal systems are active during labor and birth. These involve oxytocin, the hormone of love; endorphins, hormones of pleasure and transcendence; epinephrine and norepinephrine, hormones of excitement; and prolactin, the mothering hormone. These systems are common to all mammals and originate in our mammalian or middle brain, also known as the limbic system. For birth to proceed optimally, this part of the brain must take precedence over the neocortex, or rational brain. This shift can be helped by an atmosphere of quiet and privacy, with, for example, dim lighting and little conversation, and no expectation of rationality from the laboring woman. Under such conditions a woman intuitively will choose the movements, sounds, breathing, and positions that will birth her baby most easily. This is her genetic and hormonal blueprint. All of these systems are adversely affected by current birth practices. Hospital environments and routines are not conducive to the shift in consciousness that giving birth naturally requires. A woman’s hormonal physiology is further disturbed by practices such as induction, the use of pain killers and epidurals, caesarean surgery, and separation of mother and baby after birth. Hormones in Birth
Perhaps the best-known birth hormone is oxytocin, the hormone of love, which is secreted during sexual activity, male and female orgasm, birth, and breastfeeding. Oxytocin engenders feelings of love and altruism; as Michel Odent says, “Whatever the facet of Love we consider, oxytocin is involved.”(1) Oxytocin is made in the hypothalamus, deep in our brains, and stored in the posterior pituitary the “master gland”, from where it is released in pulses. It is a crucial hormone in reproduction and mediates what have been called the ejection reflexes: the sperm ejection reflex with male orgasm (and the corresponding sperm introjection reflex with female orgasm); the fetal ejection reflex at birth (a phrase coined by Odent for the powerful contractions at the end of an undisturbed labor, which birth the baby quickly and easily)(2); and, postpartum, the placental ejection reflex and the milk ejection or let-down reflex in breastfeeding. As well as reaching peak levels in each of these situations, oxytocin is secreted in large amounts in pregnancy, when it acts to enhance nutrient absorption, reduce stress, and conserve energy by making us more sleepy. (3) Oxytocin also causes the rhythmic uterine contractions of labor, and levels peak at birth through stimulation of stretch receptors in a woman’s lower vagina as the baby descends. (4) The high levels continue after birth, culminating with the birth of the placenta, and then gradually subside. (5) The baby also has been producing oxytocin during labor, perhaps even initiating labor;(6) so, in the minutes after birth, both mother and baby are bathed in an ecstatic cocktail of hormones. At this time ongoing oxytocin production is enhanced by skin-to-skin and eye-to-eye contact and by the baby’s first suckling. Good levels of oxytocin will also protect against postpartum hemorrhage by ensuring good uterine contractions. (7) In breastfeeding, oxytocin mediates the let-down reflex and is released in pulses as the baby suckles. During the months and years of lactation, oxytocin continues to act to keep the mother relaxed and well nourished. One researcher calls it “a very efficient anti-stress situation which prevents a lot of disease later on.” In her study, mothers who breastfed for more than seven weeks were calmer, when their babies were six months old, than mothers who did not breastfeed. (8) Outside its role in reproduction, oxytocin is secreted in other situations of love and altruism, for example, sharing a meal. (9) Researchers have implicated malfunctions of the oxytocin system in conditions such as schizophrenia (10), autism (11), cardiovascular disease (12) and drug dependency (13), and have suggested that oxytocin may mediate the antidepressant effect of drugs such as Prozac. (14) Beta-endorphin
As a naturally occurring opiate, beta-endorphin has properties similar to meperidine (pethidine, Demerol), morphine, and heroin, and has been shown to work on the same receptors of the brain. Like oxytocin, beta-endorphin is secreted from the pituitary gland, and high levels are present during sex, pregnancy, birth, and breastfeeding. Beta-endorphin is also a stress hormone, released under conditions of duress and pain, when it acts as an analgesic and, like other stress hormones, suppresses the immune system. This effect may be important in preventing a pregnant mother’s immune system from acting against her baby, whose genetic material is foreign to hers. Like the addictive opiates, beta-endorphin induces feelings of pleasure, euphoria, and dependency or, with a partner, mutual dependency. Beta-endorphin levels are high in pregnancy and increase throughout labor, (15) when levels of beta-endorphin and corticotrophin (another stress hormone) reach those found in male endurance athletes during maximal exercise on a treadmill. (16) Such high levels help the laboring woman to transmute pain and enter the altered state of consciousness that characterizes an undisturbed birth. Beta-endorphin has complex and incompletely understood relationships with other hormonal systems. (17) In labor, high levels will inhibit oxytocin release. It makes sense that when pain or stress levels are very high, contractions will slow, thus “rationing labour according to both physiological and psychological stress.”(18) Beta-endorphin also facilitates the release of prolactin during labor, (19) which prepares the mother’s breasts for lactation and also aids in the final stages of lung maturation for the baby. (20) Beta-endorphin is also important in breastfeeding. Levels peak in the mother at 20 minutes, (21) and beta-endorphin is also present in breast milk, (22) inducing a pleasurable mutual dependency for both mother and baby in their ongoing relationship. Fight-or-Flight Hormones
The hormones epinephrine and norepinephrine (adrenaline and noradrenaline) are also known as the fight-or-flight hormones, or, collectively, as catecholamines (CAs). They are secreted from the adrenal gland, above the kidney, in response to stresses such as fright, anxiety, hunger or cold, as well as excitement, when they activate the sympathetic nervous system for fight or flight. In the first stage of labor, high CA levels inhibit oxytocin production, therefore slowing or inhibiting labor. CAs also act to reduce blood flow to the uterus and placenta, and therefore to the baby. This makes sense for mammals birthing in the wild, where the presence of danger would activate this fight or flight response, inhibiting labor and diverting blood to the major muscle groups so that the mother can flee to safety. In humans, high levels of CAs have been associated with longer labor and adverse fetal heart rate patterns (an indication of stress to the baby). (23) Ecstatic Birth  Sarah J Buckley. Page 2 After an undisturbed labor, however, when the moment of birth is imminent, these hormones act in a different way. There is a sudden increase in CA levels, especially noradrenaline, which activates the fetal ejection reflex. The mother experiences a sudden rush of energy; she will be upright and alert, with a dry mouth and shallow breathing and perhaps the urge to grasp something. She may express fear, anger, or excitement, and the CA rush will cause several very strong contractions, which will birth the baby quickly and easily. Some birth attendants have made good use of this reflex when a woman is having difficulties in the second stage of labor. For example, one anthropologist working with an indigenous Canadian tribe recorded that when a woman was having difficulty in birth, the young people of the village would gather together to help. They would suddenly and unexpectedly shout out close to her, with the shock triggering her fetal ejection reflex and a quick birth (24). After the birth, the mother’s CA levels drop steeply, and she may feel shaky or cold as a consequence. A warm atmosphere is important, as if the mother is not helped to warm up, the ongoing cold stress will keep her CA levels high, inhibiting her natural oxytocin release and therefore increasing her risk of postpartum hemorrhage. (25) Noradrenaline, as part of the ecstatic cocktail, is also implicated in instinctive mothering behavior. Mice bred to be deficient in noradrenaline will not care for their young after birth unless noradrenaline is injected back into their system (26). For the baby also, birth is an exciting and stressful event, reflected in high CA levels (27). These assist the baby during birth by protecting against the effects of hypoxia (lack of oxygen) and subsequent acidosis. High CA levels at birth ensure that the baby is wide-eyed and alert at first contact with the mother. The baby’s CA levels also drop rapidly after an undisturbed birth, being soothed by contact with the mother. Prolactin
Known as the mothering hormone, prolactin is the major hormone of breast milk synthesis and breastfeeding. Traditionally it has been thought to produce aggressively protective behavior (the “mother tiger” effect) in lactating females.(28) Levels of prolactin increase in pregnancy, although milk production is inhibited hormonally until the placenta is delivered. Levels further increase in labor and peak at birth. Prolactin is also a hormone of submission or surrender--in primate troops, the dominant male has the lowest prolactin level--and produces some degree of anxiety. In the breastfeeding relationship these effects activate the mother’s vigilance and help her to put her baby’s needs first.(29) The baby also produces prolactin in pregnancy, and high levels are found in amniotic fluid, possibly of uterine or placental origin.(30) The function of prolactin in the baby is unknown. Undisturbed Birth
Undisturbed birth is exceedingly rare in our culture, even in birth centers and home births. Two factors that disturb birth in all mammals are firstly being in an unfamiliar place and secondly the presence of an observer. Feelings of safety and privacy thus seem to be fundamental. Yet the entire system of Western obstetrics is devoted to observing pregnant and birthing women, by both people and machines, and when birth isn’t going smoothly, obstetricians respond with yet more intense observation. It is indeed amazing that any woman can give birth under such conditions. Some writers have observed that, for a woman, having a baby has a lot of parallels with making a baby: same hormones, same parts of the body, same sounds, and the same needs for feelings of safety and privacy. How would it be to attempt to make love in the conditions under which we expect women to give birth? Impact of Drugs and Procedures
Ecstatic Birth  Sarah J Buckley. Page 3 Induction and Augmentation
In Australia, approximately 20 percent of women have induced labor, and another 20 percent have an augmentation--stimulation or speeding up of labor--with synthetic oxytocin (syntocinon, pitocin) (31). In the U.S., these rates are 19.8 percent and 17.9 percent, (32) adding up in both countries to around 40 percent of birthing women being administered synthetic oxytocin by IV during labor. Synthetic oxytocin administered in labor does not act like the body’s own oxytocin. First, syntocinon-induced contractions are different from natural contractions, and these differences can cause a reduced blood flow to the baby. For example, waves can occur almost on top of each other when too high a dose of synthetic oxytocin is given, and it also causes the resting tone of the uterus to increase (33). Second, oxytocin, synthetic or not, cannot cross from the body to the brain through the blood-brain barrier. This means that syntocinon, introduced into the body by injection or drip, does not act as the hormone of love. However, it does provide the hormonal system with negative feedback—that is, oxytocin receptors in the laboring woman’s body detect high levels of oxytocin and signal the brain to reduce production. We know that women with syntocinon infusions are at higher risk of bleeding after the birth, because their own oxytocin production has been shut down. But we do not know the psychological effects of giving birth without the peak levels of oxytocin that nature prescribes for all mammalian species. As for the baby, “Many experts believe that through participating in this initiation of his own birth, the fetus may be training himself to secrete his own love hormone.”(34). Michel Odent speaks passionately about our society’s deficits in our capacity to love self and others, and he traces these problems back to the time around birth, particularly to interference with the oxytocin system. Opiate Painkillers
The most commonly used drug in Australian labor wards today is pethidine (meperidine, Demerol). In one state, 34 percent of laboring women in 1998 were given this drug.(35) In the U.S., several opiate-like drugs have been traditionally used in labor, including meperidine nalbuphine (Nubain), butorphanol (Stadol), alphaprodine (Nisentil), hydromorphone (Dilaudid), and fentanyl citrate (Sublimaze). The use of simple opiates in the labor room has declined in recent years, with many women now opting for epidurals, which may also contain these drugs (see below). (36) As with oxytocin, use of opiate drugs will reduce a woman’s own hormone production, (37) which may be helpful if levels are excessive and inhibiting labor. The use of pethidine, however, has been shown to slow labor, more so with higher doses (38). Again we must ask: What are the psychological effects for mother and baby of laboring and birthing without peak levels of these hormones of pleasure and co-dependency? Some researchers believe that endorphins are the reward we get for performing reproductive functions such as mating and birthing; that is, the endorphin fix keeps us having sex and having babies (39). It is interesting to note that most countries that have adopted Western obstetrics, which prizes drugs and interventions in birth above pleasure and empowerment, have experienced steeply declining birth rates in recent years. Of greater concern is a study that looked at the birth records of 200 opiate addicts born in Stockholm from 1945 to 1966 and compared them with the birth records of their non-addicted siblings. When the mothers had received opiates, barbiturates, and/or nitrous oxide gas during labor, especially in multiple doses, the offspring were more likely to become drug addicted. For example, when a mother received three doses of opiates, her child was 4.7 times more likely to become addicted to opiate drugs in adulthood (40). This study was recently replicated with a U.S. population, with very similar results (41). The authors of the first study suggest an imprinting mechanism, but I wonder whether it may be a matter of ecstasy--if we don’t get it at birth, as we expect, we look for it later in life through drugs. Perhaps this also explains the popularity (and the name) of the drug Ecstasy. Ecstatic Birth  Sarah J Buckley. Page 4 Animal studies suggest a further possibility. It seems that drugs administered chronically in late pregnancy can cause effects in brain structure and function (eg chemical and hormonal imbalance) in offspring that may not be obvious until young adulthood (42–45). Whether such effects apply to human babies who are exposed for shorter periods around the time of birth is not known; but one researcher warns, “During this prenatal period of neuronal [brain cell] multiplication, migration and interconnection, the brain is most vulnerable to irreversible damage.”(46) Epidural Drugs
Epidural drugs are administered over several hours via a tube into the space around the spinal cord. Such drugs include local anaesthetics (all cocaine derivatives, eg. bupivicaine/marcaine), more recently combined with low-dose opiates. Spinal pain relief involves a single dose of the same drugs injected through the coverings of the spinal cord, and is usually short acting unless given as a combined spinal-epidural (CSE). Epidural pain relief has major effects on all of the above-mentioned hormones of labor. Epidurals inhibit beta-endorphin production (47) and therefore also inhibit the shift in consciousness that is part of a normal labor. This may be one reason why epidurals are so acceptable to hospital birth attendants, who are not prepared, practically or professionally, to deal with the irrationality, directness, and physicality of a woman laboring on her own terms. When an epidural is in place, the oxytocin peak that occurs at birth is also inhibited because the stretch receptors of a birthing woman’s lower vagina, which trigger this peak, are numbed. This effect probably persists even when the epidural has worn off and sensation has returned, because the nerve fibers involved are smaller than the sensory nerves and therefore more sensitive to drug effects (48). A woman giving birth with an epidural will therefore miss out on the fetal ejection reflex, with its strong final contractions designed to birth her baby quickly and safely. She must then use her own effort, often against gravity, to compensate. This explains the increased length of the second stage of labor and the extra need for forceps when an epidural is used (49). Use of epidurals also inhibits catecholamine release (50), which may be advantageous in the first stage of labor; close to the time of birth, however, a reduction in CA levels will, as with oxytocin, inhibit the fetal ejection reflex and prolong the second stage. Another hormone also appears to be adversely affected by epidurals. Prostaglandin F2 alpha helps to make a laboring woman’s uterus contractible, and levels increase when women labor without epidurals. In one study, women with epidurals actually experienced a decrease in PGF2 alpha, and average labor times were increased from 4.7 to 7.8 hours (51). Drugs administered by epidural enter the mother’s bloodstream immediately and go straight to the baby at equal, and sometimes effectively greater, levels (52, 53). Some drugs will be preferentially taken up into the baby’s brain (54), and almost all will take longer to be eliminated from the baby’s immature system after the cord is cut. For example, the ‘half life ‘of bupivacaine- the time it takes to reduce blood level by 50%- is 2.7 hours in the adult, but around 8 hours in a newborn baby (55) Another indication of the effects of epidurals on mother and baby comes from French researchers who gave epidurals to laboring sheep (56). The ewes failed to display their normal mothering behavior; this effect was especially marked for the ewes in their first lambing that were given epidurals early in labor. Seven out of eight of these mothers showed no interest in their offspring for at least 30 minutes. Some studies indicate that this disturbance may apply to humans also. Mothers given epidurals in one study spent less time with their babies in hospital, in inverse proportion to the dose of drugs they received and the length of the second stage of labor (57). In another study, mothers who had epidurals described their babies as more difficult to care for one month later (58). Ecstatic Birth  Sarah J Buckley. Page 5 Such subtle shifts in relationship and reciprocity may reflect hormonal dysfunctions and/or drug toxicity and/or the less-than-optimal circumstances that often accompany epidural births--long labors, forceps, and cesareans. Incredibly, there have been no good studies of the effects of epidurals on breastfeeding (59), although there is evidence that babies born after epidural have a diminished suckling reflexes and capacity (60,61). Caesarean Surgery
Cesarean section involves major abdominal surgery and increases the risk of maternal death by about four times (62), as well as possibly affecting mother and baby’s health in subsequent pregnancies (63). Cesarean rates are currently 21.1 percent in Australia (64) and 22.9 percent--the highest level on record--in the U.S. (65). Obviously there is a shorter or absent labor with cesarean birth, and the peaks of oxytocin, endorphins, catecholamines, and prolactin are absent. Furthermore, mothers and babies are usually separated for some hours after birth, so the first breastfeed is usually delayed. Both will also be affected to some extent by the drugs used in the procedure (epidural, spinal, or general anaesthetic) and for post-operative pain relief. The consequences of such radical departures from our hormonal blueprint are suggested in the work of Australian researchers who interviewed 242 women in late pregnancy and again after birth. The 50 percent of women who had given spontaneous vaginal birth were the most likely to experience a marked improvement in mood and an elevation of self-esteem after delivery. In comparison, the 17 percent who had caesarean surgery were more likely to experience a decline in mood and self-esteem. The remaining women had forceps or vacuum assistance, and their mood and self-esteem were, on average, unaltered (66). Another study looked at the breastfeeding hormones prolactin and oxytocin on day two, comparing women who had given birth vaginally with women who had undergone emergency cesarean surgery. In the cesarean group, prolactin levels did not rise as expected with breastfeeding, and the oxytocin pulses were reduced or absent. In this study, first suckling had been at 240 minutes average for cesarean babies, and 75 minutes average for babies vaginally born. Duration of breastfeeding was not significantly different for the mothers, and the authors conclude “other factors…can compensate for deficient hormonal release.”(67). Other research has shown that early and frequent suckling positively influences milk production and the duration of breastfeeding (68,69). The authors of the hormonal study above add, “These data indicate that early breastfeeding and physical closeness may be associated not only with more interaction between mother and child, but also with endocrine [hormonal] changes in the mother.” (70) These studies not only indicate important links between birth and breastfeeding, but also show how an optimal birth experience can influence the long-term health of mother and baby. For example, successful breastfeeding confers advantages such as reduced risk of breast cancer and osteoporosis for the mother and reduced risk of diabetes and obesity long-term for the child. And enhanced self-esteem after a natural birth- a life-long effect, in my experience -is a solid base from which to begin our mothering. The connections between events at birth and long-term health certainly deserve more study. (See Michel Odent’s
Primal Health Database for a summary of current research.) But we cannot
afford to wait for years for researchers to “prove” the benefits of an undisturbed birth. Perhaps the best we can
do is trust our instincts and vote with our birthing bodies, choosing models of care that increase our chances of
undisturbed- and ecstatic- birthing.
Early Separation
Even in non-interventionist settings, it is uncommon for the baby to remain in the mother’s arms for the first one to two hours. And yet nature’s blueprint for this time includes a specific and genetically encoded activation of the brain and nervous system for both mother and baby. For example, when the newborn baby is in skin-to-skin contact, at the mother’s left breast (which is where new mothers in all cultures instinctively cradle their babies) Ecstatic Birth  Sarah J Buckley. Page 6 and in contact with her heart rhythm, “a cascade of supportive confirmative information activates every sense, instinct and intelligence needed for the radical change of environment … thus intelligent learning begins at birth.” (71). For the mother also, “A major block of dormant intelligences is activated…the mother then knows exactly what to do and can communicate with her baby on an intuitive level.” (72) This awakening of maternal capabilities is well known among animal researchers, who link it to the action of pregnancy and birth hormones on the brain of newly delivered mothers (73). Such intuitive capacities are sorely needed in our human culture, where we rely so heavily on outside advice from books and 'experts' to tell us how to care for our babies. According to Pearce, when these activations do not occur within about 45 minutes of birth, “…cut off from his mother’s nurturing and with none of the encoded expectancies met, the newborn’s adrenals continue to release steroids in the face of maximum fear and abandonment. The infant screams for a short time and then silence falls.” The damage caused by separation, Pearce writes, is “massive and past the point of repair.” Like Odent, he believes that our current birth practices are psychologically crippling to babies, mothers, and society as a whole, and the evidence in his book Evolution’s End: Reclaiming the Potential of Our Intelligence is compelling. Optimizing the Ecstasy
The following suggestions will help a woman to use her hormonal blueprint and so optimize the experience and safety for herself and her baby. Remember that birth is “orgasmic in its essence” (75), so that conditions for birth are ideally as close as possible to conditions for lovemaking. Take responsibility for your health, healing, and wholeness throughout the child-bearing years Choose a model of care that enhances the chance of a natural and undisturbed birth (eg home birth, birth center, one-on-one midwifery care). Arrange support according to individual needs; trust, a loving relationship, and continuity of care with support people are important. Consider having an advocate at a hospital birth - eg private midwife or doula. Ensure an atmosphere where the labouring woman feels safe, unobserved, and free to follow her own instincts Reduce neocortical stimulation by - keeping lighting and noises soft and reducing words to a minimum. Cover the clock and any other technical equipment. Avoid drugs unless absolutely necessary. Avoid procedures (including obvious observations) unless absolutely necessary. Avoid caesarean surgery unless absolutely necessary. Don’t separate mother and baby for any reason, including resuscitation, which can be done with the cord still attached. One way to ensure minimum interference in the third stage is to practice Lotus Birth, or non-severance of the cord. This is only compatible with a physiological third stage, and also keeps mother and baby together and secluded in the hours and days after birth. It is the subject of a new book and, having had three Lotus-born babies myself, I highly recommend both the practice and the book (74). Giving birth is an act of love, and each birth is unique to the mother and her baby. Yet we also share the same womanly physiology and the same exquisite orchestration of our birthing hormones. Our capacity for ecstasy in birth is also both unique and universal, a necessary blessing that is hard-wired into our bodies, yet that requires, Ecstatic Birth  Sarah J Buckley. Page 7 especially in these times, that we each trust, honor, and protect the act of giving birth according to our own instincts and needs. Dutch professor of obstetrics G. Kloosterman offers a succinct summary, which would be well placed on the door of every birth room: Spontaneous labour in a normal woman is an event marked by a number of processes so complicated and so perfectly attuned to each other that any interference will only detract from the optimal character. The only thing required from the bystanders is that they show respect for this awe-inspiring process by complying with the first rule of medicine - nil nocere [Do no harm]. (76) 1. Odent MR. The Scientification of Love. Free Association Press London 1999 2. Odent M. The Fetus Ejection Reflex. In The Nature of Birth and Breastfeeding. Bergin and Garvey, CT 1994 3. Uvnas Moberg K. Quoted in report of Australian Lactation Consultant’s Conference, Gold Coast, Australia 1998. Australian Doctor 7/8/98 p38 4. Dawood MY, Raghavan KS, et al. Oxytocin in human pregnancy and parturition. Obstet Gynecol 1978;51:138-143 5. Nissen E et al. Elevation of oxytocin levels early post-partum in women. Acta Obstet Gynecol Scand 1998;74(7):530-3 6. Chard T, Hudson CN, et al. Release of oxytocin and vasopressin by the human fetus during labour. Nature 1971; 234:352-354 7. Odent M. Don’t manage the third stage of labour! The Practising Midwife 1998;1(9):31-3 9. Verbalis JG, McCann M et al. Oxytocin secretion in response to cholecystokinin and food: differentiation of nausea from satiety. Science 1986;232:1417-19 10. Feifal P, Raza T. Oxytocin modulates psychomimetic-induced deficits in sensorimotor gating. Psychopharmacology 1999;141(1):93-8 11. Insel TR Oxytocin, Vasopressin and Autism- is there a connection? Biol Psychiatry 1999;45(2):145-7 12. Knox S et al. Social Isolation and cardiovascular disease- an atherosclerotic pathway. Psychoneuroendocrinology 1998;23(8):877-90 13. Sarnyai Z, Kovacs G-L. Role of oxytocin in the neuroadaptation to drugs of abuse. Psychoneuroendocrinology 1994;19(1):85-117 14. Uvnas Moberg K et al. Oxytocin as a possible mediator of SSRI-induced antidepressant effect. Psychopharmacology 1999; 142(1):954-101 15. Brinsmead M, Smith R et al. Peripartum Concentrations of Beta Endorphin and Cortisol and Maternal Mood States. Aust NZ J Obstet Gynaecol 1985;25:194-7 16. Goland RS, Wardlaw SL et al. Biologically active corticotrophin-releasing hormone in maternal and fetal plasma during pregnancy. Am J Obstet Gynecol 1984;159:884-90 17. Laatikainen T. Corticotrophin releasing hormone and opioid peptides in reproduction and stress. Annals of Medicine 1991; 23(5):489-96 18. Jowitt M. Beta-endorphin and Stress in Pregnancy and Labour. Midwifery Matters 1993;56: 3-4 Ecstatic Birth  Sarah J Buckley. Page 8 19. Rivier C, Vale W et al. Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin. Endocrinology 1976;100:238-41 20. Mendelsen CR. Prolactin may be stimulus in fetal lung development. Ob-Gyn News 1978,July 1. 21. Franceschini R et al. Plasma beta-endorphin concentrations during suckling in lactating women. Br J Obstet Gynaecol 1989;96(6):711-3 22. Zanardo V et al. Beta endorphin concentrations in human milk. J Pediatr Gastroenterol Nutr 2001;33(2):160-4 23. Lederman R, Lederman E et al. Anxiety and epinephrine in multiparous women in labor: Relationship to duration of labor and fetal heart rate patterns. Am J Obstet Gyn 1985;153(8):870-7 25. Saito M, et al. Plasma catecholamines and microvibration as labour progresses. Shinshin-Thaku 1991;31:381-89 (Abstract in English) 26. Thomas SA, Palminter RD. Impaired maternal behavior in mice lacking norepinephrine and epinephrine. Cell 1997;91:583-92 27. Lagercrantz H, Bistoletti H. Catecholamine release in the newborn infant at birth. Pediatric Research 1977. 11889-95 30. Daniels G, Martin J. Neuroendocrine regulation and diseases of the anterior pituitary and hypothalamus. In: Harrison’s Principles of Internal Medicine 13th Ed,1994, McGraw-Hill. 31. AIHW 2000. Australian Institute of Health and Welfare National Perinatal Data Statistics Unit, 2001. Retrieved Oct 2001
32. National Centre for Health Statistics retrieved Nov 01
35. Queensland Health . Perinatal Statistics 1996. Retrieved
Nov 2001
36. ACOG- American College of Obstetricians and Gynecologists. Obstetric Analgesia and Anesthesia Technical Bulletin number 225, July 1996. 37. Thomas TA, Fletcher JE et al. Influence of medication, pain and progress in labour on plasma beta-endorphin like immunoreactivity. Br J Anaesth 1982;54:401-8 38. Thomson AM. A re-evaluation of the effect of pethidine on the length of labour. J Adv Nurs 1994;19(3):448-56 39. Kimball CD. Do endorphin residues of beta lipotrophin in hormone reinforce reproductive functions? Am J Obstet Gynecol 1979;134(2);127-32 40. Jacobsen B, Nyberg K, Gronbladh L, Eklund G, Bygdeman M, Rydberg U. Opiate addiction in adult offspring through possible imprinting after obstetric treatment. BMJ 1990; 301:1067-70 41. Nyberg K et al. Perinatal Medication as a Potential Risk Factor for Adult Drug Abuse in a North American Cohort. Epidemiology 2000;11(6):715-6 Ecstatic Birth  Sarah J Buckley. Page 9 42. Myerson BJ. Influence of early B-endorphin treatment on the behavior and reaction to B-endorphin in the adult male rat. Psychoneuroendocrinology 1985;10:135-47 43. Kellogg CK et al. Sexually Dimorphic Influence of Prenatal Exposure to Diazepam on Behavioral Responses to Environmental Challenge and on Gamma Aminobutyric Acid (GABA)-Stimulated Chloride Uptake in the Brain. J Pharmacology and Experimental Theraputics 1991;256(1):259-65 44. Mirmiran M, Swaab DF. Effects of Perinatal medication on the developing brain. In Fetal Behaviour, Nijhuis JG (Ed), Oxford University Press, Oxford 1992 45. Liverzey GT et al. Prenatal exposure to phenobarbital and quantifiable alterations in the electroencephalogram of adult rat offspring, Am J Obstet Gynecol 1992;167(6):1611-15 47.Brinsmead M, Smith R et al. Peripartum Concentrations of Beta Endorphin and Cortisol and Maternal Mood States. Aust NZ J Obstet Gynaecol 1985;25:194-7 48. Goodfellow CF, Hull MGR et al. Oxytocin deficiency at delivery with epidural analgesia. Br J Obstet Gynaecol 1983; 90:214-9 49. McRae-Bergeron CE et al. The effect of epidural analgesia on the second stage of labour. J Am Assoc Nurse Anesth (AANAJ)1998;66(2):177-82 50. Falconer AD, Powles AB. Plasma noradrenaline levels during labour. Influence of elective lumbar epidural blockade. Anaesthesia 1982;37:416-20 51. Behrens O et al. Effects of lumbar epidural analgesia on prostaglandin F2 alpha release and oxytocin secretion during labour. Prostaglandins 1993;45(3):285-96 52. Fernando R, Bonello E. Placental and maternal plasma concentrations of fentanyl and bupivicaine after ambulatory combined spinal epidural (CSE) analgesia during labour. Int J Obst Anesth 1995;4:178-9 53. Brinsmead M. Fetal and neonatal effects of drugs administered in labour. Med J Australia 1987;146:481-6 54. Hale T. The effects on breastfeeding women of anaesthetic medications used during labour. Paper presented at Passage to Motherhood Conference, Brisbane 1998. Contact CAPERS bookshop, Brisbane for abstracts or tape. 55. Hale, T. Medications and Mother’s Milk. 6th Ed. Texas, Pharmasoft Medical Publishing, 1997 56. Krehbiel DP, Poindron F et al. Peridural Anesthesia Disturbs Maternal Behavior in Primiparous and Multiparous Parturient Ewes. Physiol Behav 1987;40:463-72 57. Sepkoski CB, Lester G et al. The effects of maternal epidural anesthesia on neonatal behavior during the first month. Dev Med Child Neurol 1992;34:1072-80 58. Murray AD, Dolby RM et al. Effects of Epidural Anaesthesia on Newborns and Their Mothers. Child Dev 1981;52:71-82 59 Walker, M. Do Labor Medications Affect Breastfeeding? J Hum Lact 1997;13(2):131-7 60. Riordan J et al. The effect of labor pain relief medication on neonatal suckling and breastfeeding duration. J Hum Lact 2000;16(1):7-12 61. Ransjo-Arvidson AB et al. Maternal analgesia during labor disturbs newborn behavior: effects on breastfeeding, temperature, and crying. Birth. 2001;28(1):20-1. 62. Enkin M, Keirse MJNK, Neilson J, Crowther C, Duley L, Hodnett E, Hofmeyr J. A Guide to Effective Care in Pregnancy and Childbirth. Third edition. Oxford University Press. Oxford 2000 Ecstatic Birth  Sarah J Buckley. Page 10 63. Hemminki E, Merilainen J. Long-term effects of caesarean sections: Ectopic pregnancies and placental problems. Am J Obstet Gynecol 1996;174(5):1569-74 66. Fisher J, Astbury J et al. Adverse psychological impact of operative obstetric interventions: a prospective longitudinal study. Australia New Zealand J Psych 1997;31:728-38 67. Nissen E, Uvnas-Moberg K et al. Different patterns of oxytocin, prolactin but not cortisol release during breastfeeding in women delivered by Caesarean section or by the vaginal route. Early Hum Dev 1996;45:103-18 68. Salariya EM, Easton PM et al. Duration of breastfeeding after early initiation and frequent feeding. Lancet 1978 2(8100);1141-43 69. De Chateau P, Wiberg B. Long term effect of mother-infant behaviour of extra contact during the first hour post partum. II A follow up at three months. Acta Paediatr. Scand. 1977;66:145-51 71. Pearce JC. Evolution’s End- Reclaiming the Potential of Our Intelligence. HarperSanFrancisco 1995 p 114 73. Russell JA, Douglas AJ et al. Brain preparations for maternity- adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview. Prog Brain Res 2001;133:1-38 74. Rachana, Shivam (Ed) Lotus Birth 2000 Greenwood Press, Melbourne. Available from 75 Baker, J.P. Prenatal Yoga and Natural Childbirth, silver anniversary 3rd edition, 2001. Berkeley, North Atlantic Books. 76. Kloosterman GJ.The universal aspects of birth: human birth as a socio-psychosomatic paradigm. J Psychosom Obstet Gyn 1982;1(1);35-41 Ecstatic Birth  Sarah J Buckley. Page 11


Protocol for outpatient treatment and prophylaxis of h1n1 influenza

REGION 4 PUBLIC HEALTH H1N1 Incident Management Protocol for Outpatient Treatment and Prophylaxis of H1N1 Influenza Table of Contents: A. Policy B. Procedure C. Criteria for Treatment D. Criteria for Prophylaxis E. Case Definitions F. Antiviral Treatment G. Antiviral Prophylaxis H. Special Considerations: Infants and Pregnant Women I. Dosing tables Appendix A: Pharmacy Memorand


No. 5 – 2002 Research News 1 Using plastics to track down prions Are waste treatment plants really capable of reducing the risk of BSEinfection? A new polymer indicator developed by Fraunhofer scientists,allows plant operators to quickly evaluate the extent to which theharmful pathogens have been destroyed. 2 Neon signs: colorful, better, cheaper Fraunhofer Press: Many people tak

Copyright © 2014 Medical Pdf Articles