Public release date: 7-Nov-2005 Contact: Paul Ocampo email@example.com 415-624-1224 Public Library of Science Ads for SSRI antidepressants are misleading, say researchers Consumer ads for a class of antidepressants called SSRIs often claim that depression is due to a chemical imbalance in the brain, and that SSRIs correct this imbalance, but these claims are not supported by scientific evidence,
Phs 398 (rev. 9/04), biographical sketch format pageBIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) University of Michigan, Ann Arbor, Michigan Dr. P. Borst Lab., Netherlands Cancer Institute, Dr. C.C. Wang Lab., University of CA at San Dr. N. Agabian Lab., University of CA at San A. Positions and Honors
Postgraduate Researcher, Dr. N. Agabian Lab., University of CA at San Francisco, CA Assist. Res. Biochemist I & II, Dr. N. Agabian Lab., University of CA at San Francisco, CA Staff Scientist, Seattle Biomedical Research Institute, Seattle, WA Assistant Professor, Dept. of Pathobiology, University of Washington, Seattle, WA Senior Scientist, Seattle Biomedical Research Institute, Seattle, WA Associate Member, Seattle Biomedical Research Institute, Seattle, WA Associate Professor, Dept. of Pathobiology, University of Washington, Seattle, WA 2003-present Member, Seattle Biomedical Research Institute, Seattle, WA 2004-present Adjunct Professor, Dept. of Microbiology, University of Washington, Seattle, WA 2005-2008 Professor, Dept. of Pathobiology, University of Washington, Seattle, WA 2005-present Adjunct Professor, Dept. of Oral Biology, University of Washington, Seattle, WA 2007-present Adjunct Professor, Dept, of Global Health, University of Washington, Seattle, WA Honors and Professional Activities
N.I.H./N.I.A.I.D. Postdoctoral Fellowship New Investigator Award, Center for AIDS Research, UCSF New Investigator Award, University Wide AIDS Research Program, State of California. New Investigator Award, Murdock Charitable Trust Investigator Award in Molecular Pathogenic Mycology, Burroughs Wellcome Chair Elect/Chair/Past Chair, Division F Medical Mycology, American Society for Microbiology ASM Council - Division Councilor at Large, American Society for Microbiology
B. Most recent peer-reviewed publications (from a total of 71)
1. Naglik, J.R., Newport, G., White, T.C., Fernandes-Naglik, L.L., Greenspan, J.S., Greenspan, D., Sweet,
S.P., Challacombe, S.J. and Agabian, N. (1999) In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis. Infection and Immunity 67:2482-2490. 2. Marr, K.A., Rustad, T.R., Rex, J.H., and White, T.C. (1999) The trailing endpoint phenotype in antifungal
susceptibility testing is pH-dependent. Antimicrobial Agents and Chemotherapy 43(6): 1383-1386 White, T.C., Minassian, B., Huczko, E. and Bonner, D.P. (1999) In vitro antifungal
activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole. Diagnostic Microbiology and Infectious Disease 35(1):163-167. 4. Marr, K.A., Seidel, K., White, T.C. and Bowden, R.A. (2000) Candidemia in allogeneic blood and marrow
transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole. J. of Infect. Dis. 181:309-316. 5. Lamb, D.C., Kelly, D.E., White, T.C. and Kelly, S.L. (1999) The R467K amino acid substitution in Candida
albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity. Antimicrobial Agents and Chemotherapy 44(1):63-67. White, T.C. (2000) Transcriptional analyses of antifungal drug resistance in Candida
albicans. Antimicrobial Agents and Chemotherapy 44(9):2296-2303 7. Marr, K.A., Ha, K., Lyons, C.N., Rustad, T.R., and White, T.C. (2001) Inducible azole resistance
associated with a heterogeneous phenotype in Candida albicans. Antimicrobial Agents and Chemotherapy 45(1):52-59. 8. White, T.C. (2001) Therapeutic failure and possible involvement of drug resistance: Known causes of
systemic antimycotic treatment failure. Cutis 67(4): S38-41. 9. Harry, J.B., Song, J.L., Lyons, C.N. and White, T.C. (2001) Transcription initiation of genes associated
with resistance in Candida albicans. Medical Mycology, 40: 73-81. 10. Rustad, T.R., Stevens, D.A., Pfaller, M.A. and White, T.C. (2002) Homozygosity at the Candida albicans
MTL loci associated with azole resistance. Microbiology 148:1061-1072. 11. White, T.C., Holleman, S., Dy, F., Mirels, L.F. and Stevens, D.A. (2002) Analysis of resistance
mechanisms in clinical isolates of Candida albicans. Antimicrobial Agents and Chemotherapy 46(6):1704-1713. 12. Starr, J.R., White, T.C., Leroux, B., Soares Luis, H., Bernardo, M., Leitao, J., and Roberts, M.C. (2002)
Persistence of oral Candida albicans carriage among healthy Portuguese schoolchildren followed for three years. Oral Microbiology and Immunology 17:304-310. 13. Song, J.L. and White, T.C. (2003) RAM2: An Essential Gene in the Prenylation Pathway of Candida
albicans. Microbiology 149(1):249-259. 14. Jurevic, R.J., Bai, M., Chadwick, R.B., White, T.C. and Dale, B.A. (2003) Single nucleotide polymorphisms
in human beta-defensin 1: High throughput SNP assays and association with Candida carriage in type 1 diabetics and non-diabetic controls. J. Clin. Micro. 41(1): 90-96. 15. Song, J.L., Lyons, C.N., Holleman, S., Oliver, B.G. and White, T.C. (2003) Antifungal activity of fluconazole
in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans. Medical Mycology 41(5): 417-425. 16. Song, J.L., Harry, J.B., Eastman, R.T., Oliver, B.G. and White, T.C. (2004) The Candida albicans
lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs. Antimicrobial Agents and Chemotherapy 48(4): 1136-1144 17. Silver, P.M., Oliver, B.G. and White, T.C. (2004) Role of Candida albicans Upc2p transcription factor in
drug resistance and sterol metabolism. Eukaryotic Cell 3(6): 1391-1397. 18. Stevens, D.A., White, T.C. et al. (2004) Studies of the paradoxical effect of caspofungin at high drug
concentrations.” Diagnostic Microbiology and Infectious Disease 51(3):173-178. 19. Harry, J.B., Oliver, B.G., Song, J.L., Little, J.T., Choiniere, J., and White, T.C. (2005) Drug induced
regulation of the MDR1 promoter in Candida albicans. Antimicrobial Agents and Chemotherapy 49(7): 2785-2792. 20. Rustad, T.R., Choiniere, J.H., Howard, D.H. and White, T.C. (2006) The Candida albicans mating type
like locus (MTL) is not involved in chlamydospore formation. Medical Mycology 44: 677-681. 21. Oliver, B.G., Song, J.L., Choiniere, J.H., and White, T.C. (2007) cis-acting Elements within the Candida
albicans ERG11 Promoter mediate the Azole Response through the Transcription Factor Upc2p. Eukaryotic Cell 6(12): 2231-2239. PMID: 17951521 22. Silver, P.M., Oliver, B.G. and White, T.C. (2007) Characterization of caspofungin susceptibilities by broth
and agar in Candida albicans clinical isolates with characterized mechanisms of azole resistance.” Medical Mycology 46 (3): 231-239. 23. Oliver, B.G., Silver, P.M., Marie, C., Hoot, S.J., Leyde, S.E. and White, T.C. (2007) Tetracycline alters
antifungal drug susceptibility in pathogenic fungi. Microbiology 154 (3): 960-970. 24. Oliver, B.G., Silver, P.M. and White, T.C. (2008) Polyene susceptibility is dependent on nitrogen source in
the opportunistic pathogen Candida albicans. Journal of Antimicrobial Chemotherapy 61: 1302-1308. 25. Richards, T.S., Oliver, B.G. and White, T.C. (2008) Micafungin Efficacy is Not Influenced by Azole
Resistance Mechanisms in Candida albicans. Journal of Antimicrobial Chemotherapy 62: 349-355; (doi:10.1093/jac/dkn156). 26. Hoot, S.J., Oliver, B.G. and White, T.C. (2008) Candida albicans UPC2 is transcriptionally induced in
response to antifungal drugs and anaerobicity through Upc2p dependent and independent mechanisms. Microbiology (in press) 27. Marie, C., Leyde, S.E., and White, T.C. (2008) Dual localization of sterol regulatory elements in S.
cerevisiae. Fungal Genetics and Biology (E-publication ahead of print: doi: 10.1016/j.fgb.2008.07.004). 28. White, T.C., Oliver, B.G., Gräser, Y. and Henn, M.R. (2008) Generating and testing molecular hypotheses
in the Dermatophytes. Eukaryotic Cell 7(8): 1238-1245. (doi:10.1128/EC.00100-08). C. Research Support
R01 DE17078 (T. White, PI)
NIH National Inst. of Dental & Cranofacial Research AIDS Related Oral Candidiasis: Drugs, Sterols and Fungal Cells
The long-range objective of this study is to understand how a fungal cell responds to azoles by studying drug
import across the plasma membrane, transcriptional activation of the sterol pathway, and environmental factors
that alter these two processes.
R01 DE11367 (T. White, PI)
NIH National Inst. of Dental & Cranofacial Research Azole Drug Resistant Candidiasis in HIV Infections
The long-range objective of this study is to understand the genetic basis behind the emergency of antifungal
resistance of Candida albicans in the HIV infected population.
R21 DE18786 (T. White, PI)
NIH National Inst. of Dental & Cranofacial Research Glucan Binding to Azole Drugs: A Novel Resistance Mechanism in Candida albicans
The long range objective of this study is to understand the role of glucan in the cell wall in azole drug
No overlap in the grants.
R01 DE14161 (T. White, PI)
NIH National Inst. of Dental & Cranofacial Research
Azoles and Candida in AIDS - A Whole Cell Response
The goal of this grant was to understand the effect of azole resistance on virulence and other characteristics of
the fungal pathogen Candida albicans including cell morphology, switching, mating, and protease expression.
R21 DE015528-01 (T. White, PI)
NIH National Inst. of Dental & Cranofacial Research
In Vivo Expression of Candida Drug Resistance Genes
The long-range objective of this study was to characterize the quantitative expression patterns of C. albicans
resistance genes in oral samples from HIV patients to understand the mechanisms of resistance in vivo.
CANCIDAS grant (T. White, PI)
Merck School Grants
Caspofungin Susceptibility of Azole-Resistant Candida albicans
The objective of this study was to determine the caspofungin susceptibility of 70 strains of C. albicans with well
characterized mechanisms of azole resistance.
R01 AI64085 (B.Wong, PI; T. White subcontract)
NIH National Inst. of Allergy and Infectious Diseases
Mechanism of Drug Resistance in Candida Albicans
For this subcontract, Dr. White's laboratory performed susceptibility testing and gene expression studies on
strains from Dr. Wong.
LES ADOLESCENTS ET LES ASSUÉTUDES Préfet des Etudes, A.R. Fragnée-LiègeMaître de Conférences-Université de Liègel’évidence. Par contre, entre la négation pure et simple du problème à coup de répression, d’exclusion et de refusd’inscription et un laxisme aveugle tendant à ne gommerL’importance croissante que connaissent le commerce que la partie la plus visible de l’ic