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Integration of capecitabine (X) into adjuvant therapy comprising
docetaxel (T) followed by 5-FU, epirubicin, and cyclophosphamide
(CEF): Efﬁcacy in patients with triple-negative breast cancer (BC).
H. Joensuu, P. Kel okumpu-Lehtinen, R. Huovinen, A. Jukkola-Vuorinen, M. Tanner, R. Kokko, J. Ahlgren, P. Bono, P. Auvinen, H. Lindman; Helsinki University Central Hospital, Helsinki, Finland; Department of Oncology, Tampere University Hospital, Tampere, Finland; Department of Oncology, Turku University Central Hospital, Turku, Finland; Department of Oncology and Radio therapy, Oulu University Hospital, Oulu, Finland; Kanta-Häme Central Hospital, Hämeenlinna, Finland; Gävle Hospital, Gävle, Sweden; Depart ment of Oncology, Helsinki University Central Hospital, Helsinki, Finland; Department of Oncology, Kuopio University Hospital, Kuopio, Finland; Uppsala University Hospital, Uppsala, Sweden Background: Interim data from this phase III randomized trial (FinXX) evaluating the integration of
capecitabine into anthracycline-/taxane-based adjuvant therapy for early BC were recently published (Lancet Oncol 2009); the present subgroup analysis explores the efﬁcacy results in patients with triple- negative BC.
Methods: 1,500 patients with axillary node-positive or high-risk node-negative (tumor size > 20 mm,
progester one receptor-negative) BC were randomized to the X-containing regimen: 3x XT (X 900 mg/m2 bid d1–14 and T 60 mg/m2 iv d1, q21d) followed by 3x CEX (C 600 mg/m2 iv d1, E 75 mg/m2 iv d1 and X 900 mg/m2 bid d1–14, q21d; n = 753), or the control regimen: 3x T (80 mg/m2 iv d1, q21d) followed by 3x CEF (C 600 mg/m2, E 75 mg/m2 and F 600 mg/m2 all d1, q21d; n = 747) in January 2004 to May 2007. The primary endpoint was recurrence-free survival (RFS) and the median follow-up time 3 yrs.
Results: RFS was signiﬁcantly increased with the X-containing therapy compared with control (92.5% vs.
88.9%; Cox proportional hazards model hazard ratio [HR] 0.66, 95% CI 0.47–0.94; p = 0.020). Overall, patients without triple-negative disease (n = 1,294) had longer RFS than those with triple-negative cancer (n = 202; HR 0.43, 95% CI 0.29–0.63; p < 0.001). Within the triple-negative BC subgroup, patients in the X arm (n = 93) achieved a longer RFS than those in the control arm (n = 109; HR: 0.43, 95% CI 0.21–0.90; p = 0.024; 3-yr RFS 87.7% vs. 76.6%, respectively), representing a 57% reduction in the risk of breast cancer recurrence or death. RFS of patients with triple-negative BC treated with the X-containing regimen did not differ signiﬁcantly from RFS of the FinXX study participants whose cancer was not triple negative (HR: 0.74, 95% CI 0.38-1.41; p = 0.357).
Conclusions: In this explorative analysis the integration of X into adjuvant combination chemotherapy
reduced the risk of breast cancer recurrence substantially compared with a control regimen of standard agents in patients with triple-negative early BC. The result needs to be conﬁrmed in studies that address adjuvant X-containing chemotherapy for triple-negative BC.
All content from the American Society of Clinical Oncology Meeting Proceedings, Volume 28, No 15_suppl (May 20), 2010 All content from the American Society of Clinical Oncology Meeting Proceedings, Volume 28, No 15_suppl (May 20), 2010 Copyright American Society of Clinical Oncology 2010, All rights reserved.
Copyright American Society of Clinical Oncology 2010, All rights reserved.
C Â M A R A M U N I C I PA L Acta da Reunião Pública da Câmara Municipal do Porto, realizada em 29 de Maio de 2001 PRESENTES: O Senhor Presidente, Eng.º Nuno Magalhães Car- doso, que presidiu, e os Senhores Vereadores Eng.º Orlando BarrosG a s p a r, Prof.ª Ernestina Miranda, Dr.ª Maria José Azevedo, Dr.ª MariaManuela Vieira, Prof. António Hernâni Gonçalves, Dr. José