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Package leaflet: Information for the user
Brevoxyl 4% Cream
Read all of this leaflet carefully because it contains important information for you.
This medicine is available without prescription. However, you still need to use Brevoxyl carefully to get the
best results from it.
-
Keep this leaflet. You may need to read it again. Ask your pharmacist if you need more information or advice. You must contact a doctor if your symptoms worsen or do not improve. If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, tell your doctor or pharmacist.
In this leaflet:
1.
What Brevoxyl is and what it is used for What Brevoxyl is and what it is used for

The name of your medicine is Brevoxyl 4% Cream (called Brevoxyl in this leaflet). Brevoxyl contains an
active substance called benzoyl peroxide.
Benzoyl peroxide works by killing bacteria on your skin that cause acne.
Brevoxyl is used to treat moderate acne (spots). It helps to:
reduce the number of spots stop new blackheads, whiteheads and spots from forming.
Brevoxyl is for use by adults and adolescents aged twelve years or over

2.
Before you use Brevoxyl

Do not use Brevoxyl:
if you are allergic (hypersensitive) to benzoyl peroxide or any of the other ingredients (listed in
Do not use Brevoxyl if the above applies to you. If you are not sure, ask your pharmacist or doctor before
you use this medicine.
Take special care with Brevoxyl
Only use Brevoxyl on your skin. Keep it away from areas like your eyes, eyelids, lips, mouth and inside the nose. If contact with these areas occurs, immediately wash the affected area with water. Take care to avoid using Brevoxyl on broken skin; for example, if you have cuts or grazes.
Take care when using Brevoxyl on areas of sensitive skin such as your neck.
Brevoxyl can make your skin more sensitive to the harmful effects of the sun. Avoid the use of
sunbeds/lamps and minimise the time you spend in the sun. You should use a sunscreen and wear protective clothing while using Brevoxyl. Avoid contact with hair, dyed or coloured fabrics (including clothing, towels and bed linen) furniture or carpeting. Brevoxyl can bleach these materials.

Children
Do not give this medicine to children under twelve years. It is not known if it works or if it is safe for them.
Using other medicines
Tell your doctor or pharmacist if you are taking any other medicines,
if you’ve taken any recently, or if
you start taking new ones. This includes medicines bought without a prescription.

In particular, tell your doctor or pharmacist:
if you are using any other acne treatment. If used at the same time, it may make skin irritation worse if you are using other acne medicines containing tretinoin, isotretinoin or tazarotene. If used at the same time, Brevoxyl may make these treatments less effective if you are using sulphonamide-containing products such as dapsone and sulfacetamide. If used at the same time as Brevoxyl, your skin or facial hair may turn yellow or orange. This will not be permanent.
Check with your doctor or pharmacist if you think any of these may apply to you. Your doctor or
pharmacist will decide if you should take Brevoxyl with these medicines or you may need to use your
medicines at different times of the day (for example, one in the morning and the other at bedtime).

Pregnancy and breast-feeding
Ask your doctor or pharmacist for advice before using Brevoxyl if you are pregnant or breast-feeding.
There is only limited information about the safety of Brevoxyl in pregnant women.
Tell your doctor or pharmacist if you are pregnant, planning to become pregnant or become
pregnant during treatment with Brevoxyl.
It is not known whether benzoyl peroxide can pass into breast milk. If you are breast-feeding, you must
check with your doctor or pharmacist before you use Brevoxyl
Do not use Brevoxyl on your breast if you are breast-feeding.

Important information about some of the ingredients of Brevoxyl
Brevoxyl contains propylene glycol alginate. This may cause skin irritation. Brevoxyl contains stearylalcohol and cetyl alcohol. These may cause local skin reactions (e.g. How to use Brevoxyl
Always use Brevoxyl exactly as your doctor or pharmacist has told you to. Check with your doctor or pharmacist if you are not sure. Use Brevoxyl once or twice a dayas instructed by your doctor or pharmacist.
Start with one application daily, preferably in the evening, then gradually increase to twice daily (morning
and evening), as instructed.
During the first weeks of treatment a sudden increase in peeling and reddening of the skin will occur in most people. If this causes you problems, try using Brevoxyl less often, or stop using it for a few days until the irritation goes away then start again. Stop using Brevoxyl if the irritation does not go away. It may take 4 to 6 weeks before you see an improvement of your skin. You may need to use this treatment for longer before you see the full effects. This is normal for acne treatments. After 6 to 8 weeks if your acne is no better or it gets worse, talk to your doctor or pharmacist. Use Brevoxyl for as long as your doctor or pharmacist tells you to. Continue using this medicine until the Do not stop using it without asking for advice. If you stop too soon your acne may come back.
How to apply Brevoxyl
1.
Completely remove any make-up.
2.
Wash your hands and the affected area and gently dry.
3. Put a thin layer of Brevoxyl cream on the affected skin using your fingertips. If the cream does not rub
into your skin easily, you are using too much.
4. Apply to all of the area of your skin that has acne, not just each spot. You may notice a mild burning
sensation. If this becomes severe, stop using Brevoxyl and see your doctor.
5. Take care not to use too much Brevoxyl. Applying too much, or more often than advised, will not help
your acne clear up more quickly and may cause skin irritation.
6. Wash your hands after using the cream.

If you forget to use Brevoxyl

Do not use a double dose to make up for forgotten doses. Apply the next dose at the usual time.
If you accidentally swallow Brevoxyl
Contact your doctor or pharmacist for advice. If you accidentally get Brevoxyl in your mouth, rinse it Possible side effects
Like all medicines, Brevoxyl can cause side effects, although not everybody gets them.:

Severe allergic reactions:

Severe allergic reactions have occurred in a very small number of people but their exact frequency is not
known. Signs include:
raised and itchy rash (hives) swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing collapse. 
Contact a doctor immediately if you get these symptoms. Stop taking Brevoxyl immediately.

Other side effects include:
Very common: may affect more than 1 in 10 people
peeling of the skin and redness at the site of application dryness, itching or sensitivity of the skin at the site of application Uncommon: may affect up to 1 in 100 people: Not known (cannot be estimated from the available data) At site of application: rash discoloration of the skin other skin reactions such as irritation and pain. Tell your doctor or pharmacist if any of these side effects become severe or troublesome, or if you notice any
side effects not listed in this leaflet.


5.
How to store Brevoxyl
Keep out of the reach and sight of children. Do not store above 25°C. Do not use Brevoxyl after the expiry date which is printed on the tube and carton. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. Further information

What Brevoxyl contains
• The active ingredient is benzoyl peroxide. Brevoxyl contains 4% w/w benzoyl peroxide.
• The other ingredients are: cetyl alcohol, promulgen G (stearyl alcohol, macrogol cetostearyl ether),
simethicone emulsion, propylene glycol alginate, dimethyl isosorbide, fragrance (X-23304) and water.

What Brevoxyl looks like and contents of the pack
Brevoxyl Cream is a white to off white cream and comes in 40g tubes.

Marketing Authorisation Holder and Manufacturer
Marketing Authorisation Holder:
GlaxoSmithKline UK Limited
Trading as Stiefel, Stockley Park West, Uxbridge, Middlesex UB11 1BT, UK


Manufacturer:
Stiefel Laboratories (Ireland) Ltd.
Finisklin Business Park, Sligo, Ireland.
PL 19494/0067
MA 300/00601
Date of preparation:
October 2012

Source: http://www.pharmacy2u.co.uk/Uploads/productleaflets/6cb95609-072d-4cd0-92e7-c4f72dac46e0/Brevoxyl%20Cream.pdf

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