PetTrust™ Plus chewable tablets given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. PetTrust™ Plus chewable tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).
In acceptability trials, PetTrust™ Plus chewable tablets were shown to be a palatable oral dosage form that
was consumed at first offering by the majority of dogs.
All dogs should be tested for existing heartworm infection before starting treatment with PetTrust™ Plus chewable tablets
Chewable Tablets
which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with PetTrust™ Plus chewable tablets.
While some microfilariae may be killed by the ivermectin in PetTrust™ Plus chewable tablets at the Caution: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
recommended dose level, PetTrust™ Plus chewable tablets are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a INDICATIONS:
transient diarrhea has been observed in clinical trials with ivermectin alone after treatment of some dogs that For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients
should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store at controlled room temperature of 59-86° F (15-30° C). Protect product from light.
PetTrust™ Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as ADVERSE REACTIONS:
pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely heartworm disease and for the treatment and control of ascarids and hookworms is as follows: observed (1.1% of administered doses). The following adverse reactions have been reported following the Chewable Tablets
Color Coding on
use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, Dog Weight
per Month
Blister Card and Carton
ataxia, staggering, convulsions and hypersalivation.
Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) PetTrust™ Plus ivermectin/pyrantel chewable tablets are recommended for dogs 6 weeks of age and older. than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included For dogs over 100 lbs., use the appropriate combination of these tablets.
mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive ADMINISTRATION:
Collies. Results of these trials and bioequivalency studies support the safety of ivermectin products in dogs, including Collies, when used as recommended.
Remove only one chewable tablet at a time from the blister card. Because most dogs find PetTrust™ Plus chewable tablets palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including to a small amount of dry food or placed in the back of the dog’s mouth for forced swallowing.
pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations Care should be taken that the dog consumes the complete dose, and treated animals should be observed for have been administered with ivermectin/pyrantel in a heartworm disease preventive program.
a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.
PetTrust™ Plus chewable tablets should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given HOW SUPPLIED:
within a month (30 days) after the dog’s last exposure to mosquitoes.
PetTrust™ Plus chewable tablets are available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes in convenient packs of 6 chewable tablets.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of PetTrust™ Plus chewable tablets must be given within a month (30 days) of the last dose of the For technical assistance, call FidoPharmBrands, LLC 866-PETTRUST (or 866-738-8787).
Manufactured for: FidoPharmBrands, LLC Yardley, PA 19067 USA
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same Manufactured by: Diamond Animal Health, Inc. Des Moines, IA 50327 USA
day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with PetTrust™ Plus chewable tablets and resumption of the recommended dosing regimen minimizes the PetTrust is a trademark of FidoPharmBrands, LLC opportunity for the development of adult heartworms.
Monthly treatment with PetTrust™ Plus chewable tablets also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


Microsoft word - drugs and the risk of falling_se formatted_august 27_2009.doc

DRUGS AND THE RISK OF FALLING Which drugs can increase the risk of falls? In theory ANY drug that causes one of the following effects can increase the risk of falling: As well, theoretically ANY drug that causes the following effects can increase the risk of a serious outcome if the patient falls: • Osteoporosis or reduced bone mineral density: Increased risk of fracture if

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2013-2014 STUDENT INJURY AND SICKNESS INSURANCE PLAN Designed Especially for the Students of Midland University Important: Please see the Notice on the first page of this plan material concerning student health insurance coverage. Notice Regarding Your Student Health Insurance Coverage Your student health insurance coverage, offered by UnitedHealthcare Insurance Company

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