Restoring metabolic balance in Ataxia-Telangiectasia ATM, the gene mutated in Ataxia-Telangiectasia (A-T), is serine/treonine kinase controlling different aspects of cell biology in response to DNA damage such as cell cycle progression, DNA repair and cell survival. The molecular and cellular events underlying the responses controlled by ATM are poorly understood. Recently, we have identified
Is your bunny sick - rabbit articleIs Your Bunny Sick?
Rabbits are at the bottom of the food chain and in the wild the weakest are the first
to be preyed upon. Thus, rabbits instinctively hide illnesses and injuries to avoid
detection by animals of prey. This may be a good survival tactic in the wild, but
for domestic rabbits, hiding their symptoms of illness only misleads their
caretakers and prevents prompt medical attention.
People who live with rabbits need to be particularly attentive to subtle changes in
behavior or litter box habits.
If your rabbit usually greets you with leaps and bounds and he is now lying in the
back of the cage when you approach, this could be a cause for concern. Couple
this behavior change with no droppings in his litter box and food left untouched
and you have a very sick rabbit.
What is "normal" behavior? Some rabbits jump up to greet you; some don’t. Some
rabbits are very active, running all over the house; some aren’t. In general, rabbits
mellow a bit as they age. A three month old bunny might seem hyperactive
compared to a more sedate five year old rabbit. Both activity levels are normal, just
different. But this behavior will be consistent and known to you. Any deviation of
that behavior could signal illness.
The following information is offered as a layman’s guide to some rabbit ailments.
Be sure to find a good veterinarian before your bunny gets sick. When your bunny
is ill, you need help quickly and you won’t have time to shop for a vet. If you are
ever in question about your rabbit’s health, call your veterinarian for advice.
Tooth grinding: Loud tooth grinding is a sure sign of pain. Note: This tooth
grinding is different from the softer “tooth purring": you may hear when you
snuggle and kiss Bun’s face!
Body heat: Rabbits regulate body temperature by their ears. Very cold or hot ears
could indicate a fever or a drop in body temperature. This, coupled with other
warning signs could warrant a trip to the vet.
Runny eyes or nose, labored breathing or chronic sneezing: These
could indicate an upper respiratory infection, a blocked tear duct or other
problems. See your veterinarian.
Wet chin or drooling: Usually a sign of tooth problems, or malocclusion. You
may also notice a decrease in appetite and ability to eat hard foods such as whole
carrot. See your veterinarian. Left untreated, tooth problems can lead to infection
of the jaw bone, which is very difficult to treat. Depending on the severity of the
misalignment, your rabbit’s teeth may need to be trimmed regularly. In severe
cases, teeth can be pulled.
Loss of balance or a head tilt: This is most often a sign of wry neck, which is
an inner ear infection, but could also be an indication of E.cuniculi. This can occur
very suddenly. Although treatment can be lengthy, and improvement not noticeable
for about 10 days. Wry neck may be cured if treatment is begun quickly.
Excessive itching or scratching, head shaking: Fleas, ear mites and/or fur
mites are the usual culprits. In some ear mite cases, scabs can be seen in the ear
canal. Your veterinarian will decide what treatment is needed. If one rabbit in your
house has mites, it is best to have all the rabbits checked, as mites can be
Fleas are common in the summer months. Although they may seem harmless, flea
infestations can kill rabbits, dogs and cats by causing a deadly case of anemia.
Dust your pet with 5% Sevin dust and use a flea comb (no flea collars, or flea dips
unless prescribed by a good rabbit vet). Have your carpet steam-cleaned or treated
with a commercial borate-compound product to kill the flea eggs and larvae. The
borate treatment is usually guaranteed for a year. Be sure the products used are
safety for rabbits. (Rule of thumb: if it’s safe for kittens, it is usually safe for adult
Sore hocks: This is when the fur on the rabbit’s hock, or heel, is worn down to
the bare skin or, in severe cases, to the bone. Sometimes the rabbit forms calluses
and gets along just fine. Problems arise when the skin turns into an open wound.
You may notice the rabbit favoring a foot as he tries to avoid putting weight on his
Causes are numerous, including wire cage bottoms with no resting area, a damp
resting board, wet bunny beds or dirty litter boxes. Overweight and large-breed
rabbits are particularly prone to sore hocks, as are the Rex breeds, since they do not
have a lot of padding on their feet.
If there are open wounds on your rabbit’s hocks or if the area is swollen, see your
veterinarian. To prevent sore hocks, give your rabbit a soft, clean resting area.
Also, keep your rabbit’s weight within normal range, and examine your rabbit
Blood in the urine, straining to urinate: The two may or may not go hand in hand.
While certain foods can turn urine red, actual blood in the urine can be a sign of
cancer, bladder infection or urinary stones. If your rabbit is straining to urinate or is
“leaking” puddles outside the litter box, you should be concerned. You may also
notice “urine burn”, caused when urine-soaked fur keeps the skin underneath damp
and irritated. Antibiotics may be needed, so take your rabbit to his veterinarian.
In one end, out the other: Your rabbit’s litter box contains a wealth of information.
A healthy digestive tract will produce large, round fecal pellets. Increasingly
smaller, irregularly shaped droppings or droppings strung together with fur (or
carpet) may indicate a problem. Proper grooming by you, especially during a molt
and plenty of fresh hay will help produce optimum digestive tract health, along
with appealing to the rabbit’s urge to chew.
Lumps and Bumps: Abscesses and tumors can be serious and should be
checked by your veterinarian as soon as possible.
Loss of appetite or lethargy: Even a rabbit can have a “bad hare day”. But if your
rabbit refuses his usual fresh food or any of his special treats, and seems
particularly lethargic, you should call your rabbit’s veterinarian right away. We
encourage you to observe your rabbit’s behavior, activity level and droppings daily.
Each rabbit is different and knowing what is normal behavior for your rabbit could
save his life.
Good and Bad Medicines
Oral penicillin such as Amoxicillin and Clavamox can kill your rabbit. Injectable
penicillin Procaine G with Benzathine is a fairly safe antibiotic for rabbits. Oral
penicillin destroy the good gut flora and can kill your rabbit shortly after
administration of the drug, or up to three weeks after the drug has been taken.
If there is a GI upset, good bacteria in the gut can be replaced by fecal pellets from
a healthy rabbit or with Probios (Bene-bac) supplement, obtainable through your
Good bunny antibiotics include Baytril (enrofloxacin); Diprofloxacin;
Chloramphenicol (viceton is the tablet form); Tetracycline; Trimethoprime/Sulfa
(Bactrim); Sulfamethazine; and Amalcacin and Gentomycin (short-term use only;
3-5 days due to nephrotoxicity).
Good bunny analgesics (pain medicine) include aspirin; Butorphenol (torbugesic);
and Flunixin (banamine).
Remember; do not administer any medications to your rabbit without consulting a
veterinarian well-versed in rabbit care.
House Rabbit Society, San Diego Chapter, copyright 2000
DIABETES (1 of 2) Metformin CVS (State Healthcare Generic (30 days) (Evercare) Glucophage $14 (500mg) metformin (Walmart $4) $ not avail Glucophage XR metformin ER (Walmart $4) Metaglip metformin/glipizide Glucovance metformin/glyburide Sulfonylurea CVS (State Healthcare Generic (30 days) (Evercare) glimep