Le sildénafil présent dans Kamagra exerce une inhibition réversible de la PDE5, modulant la cascade GMPc et favorisant une vasodilatation localisée. L’absorption digestive varie selon la forme utilisée, comprimés classiques ou gels oraux. La distribution tissulaire est large et la liaison protéique élevée, avoisinant 96 %. La métabolisation hépatique génère un métabolite actif contribuant à l’effet pharmacologique global. La demi-vie reste courte, avec disparition plasmatique en quelques heures. Les interactions significatives concernent surtout les nitrés organiques et inhibiteurs puissants du CYP3A4. Dans les publications techniques, kamagra en ligne est souvent cité dans le cadre d’analyses comparatives portant sur les différences de formulations et de cinétique d’absorption.

Bop antibiotic profile 2012

2012 ANTIBIOTIC SUSCEPTIBILITY PROFILES

s
u
s
s
s
c
s
u
e
a
a
s
s
c
u
tre
e
s
c
s
c
ia
lis
ilu
n
s
r /
u
u
o
s
c
e
c
n
lla
a
a
o
o
te
c
c
u
c
u
z
o
n tic
o
e
h
lla
s
c
c
c
e ly
c
o
x
p
n
m
in
li
u
ilis
c
s
o
tic
lo
re
g
m
rrh
o
e
o
g
o
ie
b
a
o
c
y
y
u
to
o me
to
u
ra
d
s
te
b
tia
c
lo
h
h
a
p
y a
p
e
o
ta
m
flu
u
ru
.c
b
p
ira
ro
y
p
p H
a
e
E
ro
ro
tre
e
h
n
M
c
a
in
e
ro
a
le
P
m
rra
te
p
p
ta
S
tre
p
H
s
K
te
n
e
n
a
S
S
P
ta
E
S
E
S
s
Number of Isolates
PENICILLIN
FLUCLOXACILLIN
AMOXYCILLIN
AMOX / CLAV
CEFACLOR
COTRIMOXAZOLE
ERYTHROMYCIN
CLINDAMYCIN
TETRACYCLINE
GENTAMICIN
CIPROFLOXACIN
NITROFURANTOIN
TRIMETHOPRIM
The p ercentage of organisms susceptible to an antibiotic is recorded (with the sample size in the first row of the table). (e.g. Staphylococcus aureus vs. flucloxacillin 90% susceptible, n=3874) S = Not specifically tested, but known to be ordinarily susceptible. R = Organism resistant or antibiotic inappropriate V = Variable susceptibility. a. S. aureus susceptible to flucloxacillin can be considered susceptible to amoxycillin-clavulanate and cefaclor. Methicillin resistant Staphylococcus aureus (i.e. MRSA) are resistant to all beta-lactam antibiotics (penicillins, cephalosporins, carbapenems). b. Clindamycin susceptibility is extrapolated from the erythromycin result. c. S. pneumoniae susceptible to penicillin can be considered susceptible to amoxycillin, amoxycillin-clavulanate, cefaclor, cefuroxime, cefotaxime, ceftriaxone, cefpodoxime, imipenem and meropenem. Confirmation of penicillin resistance (reduced susceptibility) in S. pneumoniae requires MIC testing. (Please note this figure includes both penicillin susceptible and intermediately susceptible isolates). S.pneumoniae isolates intermediately susceptible to penicillin are resistant to cefaclor. In 2012 our S. pneumoniae isolates demonstrated the following pattern of susceptibility to penicillin: 81% = Susceptible, 9% = Intermediate, 10% = Resistant. However, of the resistant strains only a few had a penicillin MIC > 4mg/L, and penicillins (amoxycillin) are effective against strains with MIC <= 4mg/L, unless they are causing meningitis. d. Amoxycillin and amoxycillin-clavulanate susceptibility is extrapolated from the penicillin result. e. Erythromycin is not recommended for treatment of infections thought to be due to H. influenzae. f. S. saprophyticus causing urinary tract infections will usually respond to amoxycillin-clavulanate and cephalosporins. (Up to 50% of isolates are resistant to amoxycillin). g. Cotrimoxazole susceptibility is extrapolated from the trimethoprim result. h. Derived from nalidixic acid result. MOST LIKELY BACTERIAL PATHOGENS IN COMMON CONDITIONS 1. RESPIRATORY INFECTIONS
2. URINARY TRACT INFECTION
Pharyngitis - Streptococcus pyogenes (Gp A 3. IMPETIGO / CELLULITIS
Acute exacerbation of Chronic Bronchitis Haemophilus influenzae Moraxella catarrhalis

Source: http://www.pathlab.co.nz/PicsHotel/PathLab/Brochure/BOP%20Antibiotic%20profile%202012.pdf