Singing Soothes: Music Concerts for the Management of Agitation in Older Adults with Dementia
Kathleen A. Clarkson, BSc; Keri-Leigh Cassidy, MD; Gail A. Eskes, PhD
ABSTRACT Background Nonpharmacological strategies for managing the behavioural and psychological symptoms of dementia are important adjuncts to medications, and evidence to support the use of nonpharmacological options is needed. We examined the effects of music concerts provided by volunteers on agitation in a group of demented older adults in their nursing home environment. Methods The study included 3 weeks of baseline, 3 weeks of daily concerts, and 3 weeks of postintervention follow-up. Agitation among the subjects was scored using the Cohen-Mansfield Agitation Inventory during the concerts as well as weekly, during each phase of the study. Results Seventeen subjects were included in the analysis. There was a near-zero incidence of agitation behaviours during the con- certs. A decrease in the weekly physical nonaggressive agitation scores of the moderately demented subjects (Mini-Mental State Examination score ≥15) after the introduction of music was also seen. In addition, subjects showed elevated nonag- gressive verbal agitation through the music phase. Conclusions Concerts provided by untrained volunteers are a resource-friendly means of managing agitation in demented older adults. Regular music programs might also help to trigger increased communicativeness and are a positive experience for caregiv- ing staff and volunteers alike. Key words: agitation, BPSD, dementia, depression, music, nonpharmacological therapy Background
the efficacy of music for BPSD has been questioned due to
Dementia is common, with an estimated prevalence of 8% in
small sample sizes, short intervention periods, a limited range
Canadians over 65 years of age.1 Nonpharmacological treat-
of outcome measures, and inconsistent results.13–17 Most
ment of the behavioural and psychological symptoms of
research has been based on highly structured music therapy
dementia (BPSD) is of interest, given the costs and adverse side
sessions or personalized, individual music interventions.
effects of medications in older adults and especially since black
These intensive approaches might not be practical for wide-
box warnings were issued for the atypical antipsychotics.2,3
spread application as they demand financial, staff, and time
Music is one intervention showing promise as a nonpharma-
resources that might be beyond the capacities of most institu-
cological alternative for managing agitation in dementia4–10
and possibly for improving mood in nondemented psychiatric
Few studies have investigated music interventions taking
patients.11,12 However, the quality of the existing literature on
place within the context of the usual nursing home clinical set-
Kathleen A. Clarkson, BSc: Dalhousie University Medical School, Halifax, Nova
Antonescul, Secretary for Seniors Mental Health Team, 7th floor Abbie J. Lane
Scotia; Keri-Leigh Cassidy, MD: Department of Psychiatry, Dalhousie Universi-
Building, 5909 Veteran’s Memorial Lane, Halifax, NS B3H 2E2; Tel: 902-425-
ty, Halifax, Nova Scotia; Gail A. Eskes, PhD: Departments of Psychiatry and Psy-
5195; Fax: 902-473-1422; E-mail: kclarkson@dal.ca
chology, Dalhousie University, Halifax, Nova Scotia
Conflict of interest: None declaredCan J Geriatr 2007;10:XX–XX.
Address for correspondence: Kathleen A. Clarkson, BSc, c/o Ms. Debbie
C a n a d i a n J o u r n a l o f G e r i a t r i c s
ting.6,8 The effectiveness of group music
in activities of daily living. A geriatric
cally evaluated. In the present study, we
establish the degree of cognitive impair-
rated by frequency from “never” (1) to
reliability24 for assessment of institution-
alized older adults. Categories of agita-
ject’s scores. In addition to the weekly
ately following lunch, 5 days a week, for
behaviours were rated as “present” or
ing to the Diagnostic and Statistical Manu-
with pianist, consisting primarily of uni-
“absent” during each concert hour. al of Mental Disorders, Fourth Revision,18
by p.r.n. use of sedative, antipsychotic,
only exclusion criterion was deafness.
contacted to explain the nature of thestudy and to seek substitute consent for
Table 1. Estimated Psychotropic Drug Equivalencies Used to Calculate Total
Sedatives (mg) Antipsychotics (mg) Antidepressants (mg)
Chart review provided demographicdata for the subjects as well as lists and
time of enrolment. Regular psychotrop-ic medications were calculated by
(antipsychotics), and paroxetine (antide-pressants) (Table 1).
*Medication standard in each of three drug categories used to calculate equivalent doses of all other relevantpsychotropic medications in each category.
C a n a d i a n J o u r n a l o f G e r i a t r i c s
M u s i c f o r t h e M a n a g e m e n t o f A g i t a t i o n i n D e m e n t i a
random.25 These subjects’ MMSE scores were 8, 16, 17, and
administered a similar questionnaire to the volunteer musi-
26 (i.e., three in the “moderate” and one in the “severe” demen-
cians, allowing them to discuss their experiences during the
tia range). The Actiwatch (model AW16, Mini-Mitter Co, Inc.,
Sunriver, OH) “watches” were placed on the nondominantwrist from 9:00 a.m. Monday to 4:00 p.m. Friday of weeks 3
(baseline), 6 (music), and 9 (postintervention follow-up) and
Subjects’ weekly scores for the CMAI subscales and the CSDD
removed only during patient bathing. The devices gathered
were averaged over each of the three study phases, and the
nondominant limb motion data at 1-minute intervals through-
means for each subscale in each phase were first analyzed by
out the 5-day period, including during sleep. For each 5-day
a mixed two-by-three analysis of variance (ANOVA; within-
phase of actigraph observation, mean motion counts were cal-
subjects factor = study phase; between-subjects factor =
culated for daytime (8:01 a.m.–8:00 p.m.) and nighttime (8:01
dementia severity group, moderate vs. severe). When these
analyses indicated that the interaction effect of phase-by-groupwas significant or marginally significant (see details below),
we conducted one-way repeated-measures ANOVA to exam-
Weekly scores for each of the subjects on the Cornell Scale for
ine the effects of phase separately for the two severity groups.
Depression in Dementia (CSDD) were completed by either
A nonsignificant phase-by-group interaction was followed by
or both of the same two primary nurses. The CSDD is an
a one-way repeated-measures ANOVA of the two severity
inventory of 19 symptoms associated with depression in
groups combined. A significant one-way ANOVA was fol-
patients who have dementia, and has established interrater
lowed by post hoc comparisons between phases using paired-
sample two-tailed t-tests. All data were analyzed using SPSSfor Windows, version 11.5.1.
Postintervention Follow-UpData collection on agitation and depression continued
throughout the follow-up phase. At the end of the study peri-
od, a questionnaire was circulated to the care staff on the unit,
Twenty-two subjects began the study; 17 completed the study
evaluating their personal reactions to the intervention and per-
and were included in the analyses. Completion was defined
ceptions of the music’s influence on the residents. A researcher
as attending a minimum of two of five concerts per week dur-
Table 2. Subject Demographic and Medication Use Profiles Prior to the Baseline Phase*
Moderate Dementia (MMSE ≥15) Severe Dementia (MMSE <15)
Mean daily sedative dosage (lorazepam equivalents [mg])
Mean daily antipsychotic dosage (haloperidol equivalents [mg])
Mean daily antidepressant dosage (paroxetine equivalents [mg])
*Presented as means and SDs (in parentheses). †On the Functional Assessment Staging (FAST), a 6c corresponds to an inability to handle the mechanics of toileting. ‡Significant statistical difference between the two groups’ means (p < .05).
C a n a d i a n J o u r n a l o f G e r i a t r i c s
ing the intervention phase. Two subjects failed to meet this cri-
Figure 1. Percent of Subjects (n = 17) in Attendance at
terion (e.g., due to having another appointment or lack of
Each Concert Through the 3-week Music Phase of the
assent on a given day), and three subjects died before the music
phase due to complications of chronic medical illness.
Table 2 shows the profiles of the subjects according to
dementia severity prior to the baseline phase. The more severe-ly demented subjects also had worse clock-drawing and FAST
scores. There were no statistically significant differences in the
groups’ demographic indices or medication usage.
Figure 1 shows the patterns of daily concert attendance
through the 3-week music phase. The total number of concerts
attended over the intervention period ranged from 8 to 15.
During the 1-hour concerts, agitation levels were extremely
low. Only two and three subjects of an average of 16.6 subjects
attending each concert in the first 2 music weeks showed any
incidence of CMAI agitation behaviours over the 10 concerts. Likewise, only two subjects of a mean of 15 attendees demon-strated any agitation in the third week’s concerts. When behav-
iours did occur, the most common were nonaggressive
Verbal nonaggression. The two-by-three ANOVA indicat-
repetitive vocalizations and mannerisms.
ed a significant effect of study phase (F[2, 30] = 4.28, p < .023)
Changes in weekly physical and verbal nonaggressive
and a nonsignificant interaction of phase-by-group (F[2, 30] =
CMAI subscale scores were variable, depending upon the
1.06, p > .05). Follow-up t-tests to examine the phase effect
(severity groups collapsed to n = 17) showed a significant rise
Physical aggression. The two-by-three ANOVA indicat-
in verbal nonaggression during the music phase (baseline vs.
ed a significant effect of phase (F[2, 30] = 5.77, p < .001) and a
music mean [SD] = 10.7 [5.4] vs. 13.0 [5.5], t[17] = 2.74, p < 0.015)
marginally significant interaction of phase-by-group (F[2, 30]
that lasted during the postintervention phase (baseline vs.
= 3.20, p < .055). One-way ANOVAs comparing the three study
postintervention mean [SD] = 10.7 [5.4] vs. 12.4 [6.7], t[17] =
phases for each group were significant for the moderately
2.93, p < .01; Figure 2d).
demented group only (F[2, 14] = 5.02, p < .023). Subsequent
Actigraphy revealed significant variation in the response
paired t-tests showed a near-significant decrease in physical
to music among the four wearers (Figure 3). Due to technical
aggression in the music phase compared with baseline (base-
problems, only three of the wearers’ data were available in
line vs. music mean [SD] = 14.0 [4.3] vs. 11.7 [1.5], t[7] = 2.23, p
week 3 (baseline). There was no obvious pattern of correlation
< .061) in the moderately demented group. This trend contin-
between mean hourly actigraph counts and CMAI physical
ued in the postintervention phase (postintervention mean [SD]
agitation totals (aggressive plus nonaggressive) in either day-
= 11.4 [1.1], t[7] = 2.27, p < .058; Figure 2a). Physical nonaggression. The two-by-three ANOVA indi-
cated a significant effect of phase (F[2, 30] = 6.81, p < .004) and
a marginally significant interaction of phase-by-group (F[2, 30]
Over the entire study period, CSDD totals ranged from 0 to 14
= 3.19, p < .056). Follow-up one-way ANOVAs comparing
out of a possible 38, corresponding to a range of “no psychi-
the phases were significant for the moderately demented
atric diagnosis” to “minor or probable major depressive dis-
group only (F[2, 14] = 5.95, p < .013). Subsequent t-tests
order.”26 No significant change was seen in the weekly CSDD
revealed a significant drop in scores in physical nonaggression
scores for either group (data not shown).
in the postintervention phase, relative to both the baseline(baseline vs. postintervention mean [SD] = 17.0 [7.3] vs. 13.2
[4.1], t[7] = 2.85, p < .025) and music phases (music vs. postin-
On the whole, the nursing home staff reflected very positive-
tervention mean [SD] = 14.5 [4.6] vs. 13.2 [4.1], t[7] = 2.46, p <
ly about the perceived effects of the music intervention on
the residents and on themselves (Table 3). The only
Verbal aggression. The two-by-three ANOVA indicated a
unfavourable response was that the nine respondents felt the
significant interaction effect of phase-by-group (F[2, 30] = 3.56,
intervention marginally increased their workload, with a mean
p < .04). However, subsequent one-way ANOVAs did not indi-
score just below 3 (neutral) out of 5.
cate significant changes over the study period for either group
The nine volunteer musicians were similarly positive in
C a n a d i a n J o u r n a l o f G e r i a t r i c s
M u s i c f o r t h e M a n a g e m e n t o f A g i t a t i o n i n D e m e n t i a
reflecting about their experiences during the study (Table 4).
All their feedback suggested a rewarding and educational
The results of this study highlight potential limitations of
the measures that we currently have for behaviour and moodin dementia. We found a paradoxical increase in
Discussion
verbal/nonaggressive “agitation” with the introduction of
In our evaluation of live music’s effects on agitation in nursing
music (see Figure 2d), despite anecdotal evidence from nurs-
home–dwelling patients with dementia, we demonstrated that
ing staff and families that participants were not more agitated
severity of dementia was an important consideration. Follow-
or difficult to manage. Rather, there were reports of positive
ing the music intervention, we found a significant reduction
changes in residents, such as singing to themselves after the
in CMAI physical/nonaggressive behaviours in moderately
concerts. There is some evidence in the literature that music
demented individuals (see Figure 2b), while all subjects
might improve communicativeness among older adults with
showed a rise in verbal/nonaggressive agitation during the
dementia. Recorded music was associated with increased ver-
music phase (see Figure 2d). To our knowledge, differential
balization in the 20 minutes postintervention in another study
effects of music depending on dementia severity have not been
of subjects with dementia.27 Informal feedback from staff and
family in this study suggest that the rise in CMAI verbal “agi-
Physical/nonaggressive agitation declined during the
tation” might simply have reflected a positive behavioural
weeks of music in the moderately demented group, but the
trend did not reach statistical significance until the postinter-
In addition, actigraphy and physical agitation measures
vention phase. Variance found among subjects’ scores in the
were poorly correlated in the few subjects for whom we had
music phase might account for the lack of a statistically signif-
these data. There was no clear relationship between limb
icant effect. It is of interest that music continued to have bene-
motion and subjective physical agitation scores (see Figure 3),
fits beyond the intervention period. Previous research notes
unlike what has been demonstrated in nondemented popula-
music’s calming effects up to 1 hour postintervention.4,7,9 We
tions.25 Similar to the difficulties faced by Brotons and Pickett-
found that music interventions impacted on weekly measures
Cooper,7 in the current study, p.r.n. psychotropic and analgesic
Figure 2. Mean Cohen-Mansfield Agitation Inventory Subscale Scores by Study Phase
Note that the maximum possible scores for each subscale differ as follows: physical/aggressive out of 77, physical nonaggressive out of 70, verbal/aggressive out of 21,and verbal/nonaggressive out of 35. Significant differences (p < .05) are noted: * = significant difference from baseline in combined groups (n = 17); + = significant dif-ference from baseline in moderate dementia group only; ++ = significant difference from music phase in moderate dementia group only.
C a n a d i a n J o u r n a l o f G e r i a t r i c s
medications were administered too infrequently to be consid-
Conventional BPSD measures also pose limitations to the
ered a valid indicator of subject agitation. Depression in
design of research in this area. Subjective rating of agitation
dementia is notoriously challenging to measure, and our find-
required that measures be completed by staff who observed
ings did not reflect any significant benefit of music on weekly
the patients closely; therefore, blinding was not possible.
observer-rated measures on mood despite anecdotal sugges-
Although we used the same CMAI for the within-concert and
tions that the patients’ mood had improved (see Table 3).
weekly measurements, the scale does not lend itself to statis-
Although the CSDD has been validated for use in the demen-
tical comparison between the two time points.
tia population,26 this conventional measure might not be sen-
Given the measures’ limitations, short duration of the
sitive enough to capture potential subtle changes in mood.
intervention, and the study being conducted in the context of
Table 3. Nursing Home Staff Feedback on the Perceived Effects of the Music Intervention*
Staff Feedback Question Mean Score (SD)†
1. How much did the residents enjoy the music?
2. How did the music affect the residents’ agitation and behaviour during concerts?
3. How much did the music impact on residents’ activity levels during concerts
(e.g., trying to leave the room, moving around)?
4. How did the music affect the residents’ memory (e.g., better recall, ability to reminisce)?
5. How much impact did the music have on their mood?
6. How did the music affect the residents’ sleep?
7. How did the music affect their overall function?
9. Did the music impact on your satisfaction in your work?
10. How much did the music concerts alleviate your workload or burden?
*Questions 1–7 elicited feedback on the perceived effects of the music intervention on the residents; questions 8–10 referred to effects on themselves (nursing home staff). †All questions were rated on a scale of 1–5, with 1 being the most negative rating, 3 neutral, and 5 the most favourable rating.
Table 4. Volunteer Musician Feedback on the Personal Effects of Participating in the Study
Volunteer Musician Feedback Question Mean Score (SD)*
3. How educational was the experience in terms of:
a. learning about working with older adults?
b. learning about working with older adults with dementia?
4. Compared with before the concert series, how much more comfortable are you:
b. interacting with older adults with dementia?
5. How likely are you to volunteer to be involved in this kind of activity again?
6. Would you recommend participating in this activity to others?
*All questions were rated on a scale from of 1–5, with 1 being the most unfavourable/negative rating, 3 neutral, and 5 the most favourable/positive rating.
C a n a d i a n J o u r n a l o f G e r i a t r i c s
M u s i c f o r t h e M a n a g e m e n t o f A g i t a t i o n i n D e m e n t i a
usual nursing home care, the statistical-
the value of subjective ratings of agita-
the practicality and cost efficiency of the
efits of music concerts for agitation.
ple size was used in the present investi-
gation due to the constraints of a closed
iours in this population. Studies of live
setting, such as a music concert, are pos-
shown that the benefits of live music can
expand on the current literature inmusic in dementia would benefit from
Figure 3. Mean Actigraph Motion Counts Per Hour*
controlling for these nonspecific factorsand using larger samples sizes. In addi-tion, the use of immediate, short-, and
interest. As in this study, the use of mul-
measures should be included. A formalinvestigation comparing the relative fea-sibility, cost efficiency, and therapeutic
Conclusions
*For each of the four actigraph wearers during representative weeks from the baseline (3), music (6), and
teers, similar to the kind of interventions
postintervention (9) phases. White bars represent daytime hours (8:01 a.m.–8:00 p.m.) and filled bars night-
time hours (8:01 p.m.–8:00 a.m.). Total values for the individuals’ weekly Cohen-Mansfield Agitation
Inventory (CMAI) physical agitation (aggressive plus nonaggressive) scores are noted above the correspon-
concerts with reductions in physical agi-
C a n a d i a n J o u r n a l o f G e r i a t r i c s
tia and with increases in verbalization in all subjects. The
Gerdner LA. Effects of individualized versus classical “relaxation”
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C a n a d i a n J o u r n a l o f G e r i a t r i c s
2006 MRAR Racer Newsletter #2 August 4, 2006 Sam Council, Course Designer Hello to everyone and welcome to the second installment of the Midnight RushAdventure Race Newsletter!These past weekends TBARC officers and your race staff have been testing yourrace course. They’ve measured distances for volunteer and race teamdirections. They’ve made pretty good timing estimates for the fastest
Propranolol and the risk of hospitalized myopathy:Translating chemical genomics findings intopopulation-level hypothesesSoko Setoguchi, MD, DrPH, a ,d John M. Higgins, MD, b,d,e Helen Mogun, MS, a Vamsi K. Mootha, MD, c andJerry Avorn, MD a Boston, MABackground A recent large-scale, chemical screening study raised the hypothesis that propranolol may increase the riskof myopathy. We tested this hy