Suomen sivusto, jossa voit ostaa halvalla ja laadukas Viagra http://osta-apteekki.com/ toimitus kaikkialle maailmaan.

Erityisesti laatu viagra tästä kaupasta voi taata henkilökohtaisesti priligy Paras laatu kehotan Teitä miellyttää.

Subject:

MedStar Health, Inc.
POLICY AND PROCEDURE MANUAL
POLICY NUMBER: PAY.122.MH
REVISION DATE: N/A
ANNUAL APPROVAL DATE: 03/13
PAGE NUMBER: 1 of 4
SUBJECT:
Genetic Testing for Clopidogrel (Plavix) Metabolism
INDEX TITLE:
Medical Management
ORIGINAL DATE:
January 2013

This policy applies to the following lines of business: (Check those that apply.)

COMMERCIAL
MedStar Select ( X )
MedStar Medicare Choice ( X )

It is the policy of MedStar Health, Inc. to cover Genetic Testing for Clopidogrel (Plavix)
metabolism when it is medically necessary as detailed in this policy and covered under
the member’s specific benefit plan.

DEFINITIONS
The purpose of this policy is to identify indications for Genetic Testing for Clopidogrel (Plavix) metabolism.
This policy applies to various MedStar Health departments as indicated by the Benefit
and Reimbursement Committee. These include but are not limited to Medical
Management, Benefit Configuration and Claims Departments.

PROCEDURE
A. Medical Description / Background
UPMC Health Plan and Evolent Health provide administrative functions and services on behalf of MedStar Health, Inc. and its affiliates. Proprietary and Confidential Information of UPMC Health Plan 2013 UPM POLICY NUMBER: PAY.122.MH
REVISION DATE: N/A
ANNUAL APPROVAL DATE: 03/13
PAGE NUMBER: 2 of 4
PLAVIX® /Clopidogrel Bisulfate, an anti-platelet agent, is commonly prescribed for patients with a history of recent myocardial infarction, stroke, or established peripheral arterial disease, acute coronary artery syndrome (ACS) as well as patients who are to be managed with percutaneous coronary intervention (PCI). CYP2C19 is one of the principal enzymes involved in the metabolism of the Clopidogrel (Plavix). The presence of CYP2C19*2, a gene variant, can cause poor metabolism of the drug which can lead to increased risk for adverse cardiovascular events. Genetic testing is available to identify a patient's CYP2C19 genotype (including the presence of gene variants) which can be used in determining the therapeutic strategy for treatment with Clopidogrel (Plavix). Examples of test names are: AccuType® CP, AccuType™ and Clopidogrel CYP2C19 genotyping. B. Indications

Genetic testing for Clopidogrel (Plavix) metabolism is covered for persons who are being considered for the drug, before treatment begins, and have not been previously tested. C. Limitations/Exclusions
Genotype test results are applied life-long, therefore, repeat genetic testing for Clopidogrel (Plavix) metabolism has no proven value. D. Variations
E. Quality Audit

Quality Audit monitors policy compliance and/or billing accuracy at the request of the
MedStar HealthTechnology Assessment Committee or the Benefits Reimbursement
Committee.
F. Records Retention

Records Retention for documents, regardless of medium, are provided within the
MedStar Health, Inc. Policy and Procedure CORP.028.MH Records Retention.
G. References
1. Holmes DR, et al. (2010). ACCF/AHA Clopidogrel clinical alert: Approaches to the FDA "Boxed Warning": A report of the American College of Cardiology Foundation Task Force on UPMC Health Plan and Evolent Health provide administrative functions and services on behalf of MedStar Health, Inc. and its affiliates. Proprietary and Confidential Information of UPMC Health Plan 2013 UPM POLICY NUMBER: PAY.122.MH
REVISION DATE: N/A
ANNUAL APPROVAL DATE: 03/13
PAGE NUMBER: 3 of 4
Clinical Expert Consensus Documents and the American Heart Association. Circulation, 122(5): 537–557 2. PubMed: Clopidogrel, 11/1/103. Mega JL, et al. (2010). Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis. JAMA, 304(16): 1821–1830 4. Paré G, et al. (2010). Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. New England Journal of Medicine, 363(18): 1704–1714 5. Michael Holmes, Pablo Perel et al: CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events A Systematic Review and Meta-Analysis, JAMA 2011;306(24):2704-2714 6. SA Scott, K Sankuhl, EE Gardner et al: Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450-2C19 (CYP2C19) Genotype and Clopidogrel Therapy, Consortium of the National Institutes of Health’s Pharmacogenomics Research Network, Clinical Pharmacology & Therapeutics, 6/29/11 7. QUEST: AccuType™ CP testing for Clopidogrel CYP2C19 Genotype (*1, *2, *3, *4, *5), 8. QUEST: AccuType® CP: Clopidogrel Response Testing, 11/12 9. ACCF/AHA Clopidogrel Clinical Alert: Approaches to the FDA “Boxed Warning, Circulation 10. BCBC Technology Evaluation Center , Assessment Program, Volume 23, No. 1, May 2008 11. Dept of Health and Human Services, AHRQ: decode Clopidogrel, Technology Assessment, 12. Dept of Health and Human Services Technology Assessment (AHRQ) Update on Horizon Genetic Tests Currently Available for Clinical Use in Cancers, 4/15/11
Disclaimer:

MedStar Health, Inc. medical payment and prior authorization policies do not constitute
medical advice and are not intended to govern or otherwise influence the practice of
medicine. The policies constitute only the reimbursement and coverage guidelines of
MedStar Health, Inc. and its affiliated managed care entities. Coverage for services
varies for individual members in accordance with the terms and conditions of applicable
Certificates of Coverage, Summary Plan Descriptions, or contracts with governing
regulatory agencies.
MedStar Health, Inc. reserves the right to review and update the medical payment and
prior authorization guidelines in its sole discretion. Notice of such changes, if necessary,
UPMC Health Plan and Evolent Health provide administrative functions and services on behalf of MedStar Health, Inc. and its affiliates. Proprietary and Confidential Information of UPMC Health Plan 2013 UPM POLICY NUMBER: PAY.122.MH
REVISION DATE: N/A
ANNUAL APPROVAL DATE: 03/13
PAGE NUMBER: 4 of 4
shall be provided in accordance with the terms and conditions of provider agreements and any applicable laws or regulations. These policies are the proprietary information of UPMC Health Plan. Any sale, copying, or dissemination of said policies is prohibited. UPMC Health Plan and Evolent Health provide administrative functions and services on behalf of MedStar Health, Inc. and its affiliates. Proprietary and Confidential Information of UPMC Health Plan 2013 UPM

Source: http://www.medstarprovidernetwork.net/files/PDF%20PAY%20Files/PAY.122.MH%20Genetic%20Test%20Clopidogrel%20(Plavix)%20Metabolism%20Ver%20Mar%2013.pdf

marianaguimaraes.art.br

o que caTam as mãos do caTa-dor? uma experiência com caTadores da ascaVap em parceria com o insTiTuTo de arTe conTemporânea inhoTim Mariana Guimarães marianasguimaraes@hotmail.com Este artigo tem como objetivo apresentar e narrar a oficina de arte-educação realizada com trabalhado-res da Associação de Catadores do Vale do Paraopeba – ASCAVAP – Brumadinho, MG.1 O trabalho foi rea

dicata.ing.unibs.it

Concrete Repair, Rehabilitation and Retrofitting II – Alexander et al (eds) © 2009 Taylor & Francis Group, London, ISBN 978-0-415-46850-3 Sulphate resistance of high volume fly ash cement paste compositesE. Aydin Cyprus International University, Mersin 10 Turkey, North Cyprus ABSTRACT: This research was carried out to evaluate the effects of using high volume Class C fly ash on streng

Copyright © 2010-2014 Medical Pdf Articles