Frutos

Currículum vitae

Javier Angulo Frutos

TITULACION ACADEMICA
Licenciado en CC. Biológicas
Especialidad de Bioquímica y Biología Molecular
Universidad Autónoma de Madrid (1986 - 1991)
Doctor en CC. Biológicas por el Dpto. de Bioquímica de la Universidad Autónoma
de Madrid (Octubre, 1996)


ACTIVIDAD INVESTIGADORA
Becario predoctoral en el Departamento de Farmacología y Terapéutica de la
Facultad de Medicina de la Universidad Autónoma de Madrid. 1992-96.
Becario postdoctoral en el Departamento de Farmacología y Terapéutica de la
Facultad de Medicina de la Universidad Autónoma de Madrid. 1996-98.
Becario postdoctoral en la Unidad de Investigación del Hospital Universitario de
Getafe. 1996-98.
Director del Laboratorio de Investigación de la Fundación para la Investigación y el
Desarrollo en Andrología / Instituto de Medicina Sexual. 1998-2006.
SITUACION ACTUAL

Contratado como Técnico Titulado Superior del Servicio de Histología,
Departamento de Investigación del Hospital Ramón y Cajal desde diciembre de
2006.
PUBLICACIONES

1. GONZALEZ R, FERNANDEZ-ALFONSO MS, RODRIGUEZ-MARTINEZ MA,
FUERTES E, ANGULO J, SANCHEZ-FERRER CF, MARIN J. Pressure-induced
contraction of the juxtamedullary afferent arterioles in spontaneously hypertensive
rats. Gen Pharmacol, 25: 333-339, 1994.
2. PEIRO C, REDONDO J, RODRIGUEZ-MARTINEZ MA, ANGULO J, MARIN J,
SANCHEZ-FERRER CF Influence of endothelium on cultured vascular smooth
muscle cell proliferation. Hypertension, 25 (part 2): 748-751, 1995.
3. ANGULO J, SANCHEZ-FERRER CF, PEIRO C, MARIN J, RODRIGUEZ-
MAÑAS L. Impairment of endothelium-dependent relaxation by increasing
percentages of glycosylated human hemoglobin. Possible mechanisms involved.
Hypertension, 28: 583-592, 1996.
4. GONZALEZ R., VILLA E, GARCIA-ROBLES R., ANGULO J, PEIRO C, MARIN
J, SANCHEZ-FERRER CF Effects of indomethacin and iloprost on the afferent
arterioles contraction by endothelin-1 in juxtamedullary nephron preparations from
normotensive Wistar Kyoto and spontaneously hypertensive rats. J Cardiovasc
Pharmacol, 28: 809-816, 1996.
5. PEIRO C, ANGULO J, REGADERA J, LLERGO J.L, SANCHEZ-FERRER A,
RODRIGUEZ-MAÑAS L, SANCHEZ-FERRER CF Nifedipine, losartan and captopril
effects on hyperplasia of vascular smooth muscle from Ren-2 transgenic rats. Eur J
Pharmacol, 324: 257-265, 1997.
6. PEIRO C, LLERGO J.L, ANGULO J, LOPEZ-NOVOA J.M., RODRIGUEZ-
LOPEZ A, RODRIGUEZ-MAÑAS L, SANCHEZ-FERRER CF Effects of captopril,
losartan, and nifedipine on cell hypertrophy of cultured vascular smooth muscle
from hypertensive Ren-2 transgenic rats. Br J Pharmacol, 121: 1438-1444, 1997.
7. PEIRO C, ANGULO J, LLERGO JL, RODRIGUEZ-MAÑAS L, MARIN J,
SANCHEZ-FERRER CF: Angiotensin II mediates cell hypertrophy in vascular
smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride-
and furosemide-sensitive mechanism. Biochem Biophys Res Commun, 240: 367-
371, 1997.
8. PEIRO C, RODRIGUEZ-LOPEZ AM, ANGULO J, REGADERA J, MARIN J,
SANCHEZ-FERRER CF, LOPEZ-NOVOA JM: Endogenous angiotensin II and cell
hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic
rats. Cell Physiol Biochem, 8: 160-, 1998.
9. RODRIGUEZ-MAÑAS L, ANGULO J, PEIRO C, LLERGO JL, SANCHEZ-
FERRER A, LOPEZ-DORIGA P, SANCHEZ-FERRER CF: Endothelial dysfunction
and metabolic control in streptozotocin-induced diabetic rats. Br J Pharmacol, 123:
1495-1502, 1998.
10. PEIRO C, ANGULO J, RODRIGUEZ-MAÑAS L, LLERGO JL, VALLEJO S,
CERCAS E, SANCHEZ-FERRER CF: Vascular smooth muscle cell hypertrophy
induced by glycosylated human oxyhaemoglobin. Br J Pharmacol, 125: 637-644,
1998.
11. ANGULO J, RODRIGUEZ-MAÑAS L, PEIRO C, NEIRA M, MARIN J,
SANCHEZ-FERRER CF: Impairment of nitric oxide mediated relaxations in
anaesthetized autoperfused streptozotocin-induced diabetic rats. Naunyn-
Schmiedeberg’s Arch Pharmacol, 358: 529-537, 1998.
12. LUJAN M, PAEZ A, LLANES L, ANGULO J, BERENGUER A: Role of
autonomic innervation in rat prostatic structure maintenance: a morphometric
analysis. J Urol, 160: 1919-1923, 1998.

13. ANGULO J, RODRIGUEZ-MAÑAS L, PEIRO C, VALLEJO S, SANCHEZ-
FERRER A, SANCHEZ-FERRER CF: Impairment of endothelial relaxations by
glycosylated human oxyhemoglobin depends on the oxidative state of the heme
group. Gen Pharmacol, 32: 475-481, 1999.
14. SAENZ DE TEJADA I, GARVEY DS, SCHROEDER JD, SHELEKIN T, LETTS
LG, FERNANDEZ A, CUEVAS B, GABANCHO S, MARTINEZ V, ANGULO J,
TROCHA M, MAREK P, CUEVAS P, TAM SW: Design and evaluation of
nitrosylated α-adrenergic receptor antagonists as potential agents for the treatment
of impotence. J Pharmacol Exp Ther, 290: 121-128, 1999.
15. SANCHEZ-FERRER CF, ANGULO J, VALLEJO S, PEIRO C, LLERGO JL,
SANCHEZ-FERRER A, CERCAS E, RODRIGUEZ-MAÑAS L: Relación entre
control metabólico y disfunción endotelial en ratas diabéticas. Nefrología, 19 (Suppl
1): 53-58, 1999.
16. PEIRO C, VALLEJO S, NEVADO J, ANGULO J, LLERGO JL, CERCAS E,
RODRIGUEZ-MAÑAS L, SANCHEZ-FERRER CF. Pharmacological interference of
vascular smooth muscle cell hypertrophy induced by glycosylated human
oxyhaemoglobin. Eur J Pharmacol, 386: 317-321, 1999.
17. VALLEJO S, ANGULO J, PEIRO C, NEVADO J, SANCHEZ-FERRER A,
PETIDIER R, SANCHEZ-FERRER CF, RODRIGUEZ-MAÑAS L. Highly glycated
oxyhaemoglobin impairs nitric oxide relaxations in human mesenteric microvessels.
Diabetologia, 43: 83-90, 2000.
18. VALLEJO S, ANGULO J, PEIRO C, CERCAS E, SANCHEZ-FERRER A,
NEVADO J, LLERGO JL, RODRIGUEZ-MAÑAS L, SANCHEZ-FERRER CF.
Treatment with acarbose may improve endothelial dysfunction in streptozotocin-
induced diabetic rats. J Cardiovasc Pharmacol, 36: 255-262, 2000.
19. VALLEJO S, ANGULO J, PEIRO C, SANCHEZ-FERRER A, CERCAS E,
NEVADO J, SANCHEZ-FERRER CF, RODRIGUEZ-MAÑAS L. Correction of
glycosylated
vasodilatation by gliclazide. J Diabetes Complications, 14: 207-214, 2000.
20. VALLEJO S, ANGULO J, PEIRO C, SANCHEZ-FERRER A, CERCAS E,
LLERGO JL, NEVADO J, SANCHEZ-FERRER CF, RODRIGUEZ-MAÑAS L.
Prevention of endothelial dysfunction in streptozotocin-induced diabetic rats by
gliclazide treatment. J Diabetes Complications, 14: 224-233, 2000.
21. ANGULO J, CUEVAS P, MONCADA I, MARTIN-MORALES A, ALLONA A,
FERNANDEZ A, GABANCHO S, NEY P, SAENZ DE TEJADA I. Rationale for the
combination of PGE1 and S-nitroso glutathione to induce relaxation of human penile
smooth muscle. J Pharmacol Exp Ther, 295: 586-593, 2000.
22. ANGULO J, CUEVAS P, FERNANDEZ A, GABANCHO S, SAENZ DE TEJADA
I. Combination of phentolamine and L-arginine or sidenafil synergistically improves
neurogenic relaxation of rabbit corpus cavernosum smooth muscle. Urology, 57:
585-589, 2001.
23. SAENZ DE TEJADA I, ANGULO J, CUEVAS P, FERNÁNDEZ A, MONCADA I,
ALLONA A, LLEDÓ E, KÖRSCHEN HG, NIEWÖHNER U, HANING H, PAGES E,
BISCHOFF E. The phosphodiesterase inhibitory selectivity and the in vitro and in
vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 13: 282-289,
2001.
24. ANGULO J, PEIRO C, SANCHEZ-FERRER CF, GABANCHO S, CUEVAS P,
GUPTA S, SAENZ DE TEJADA I. Differential effects of serotonin reuptake inhibitors
on erectile responses, NO-production, and neuronal NO synthase expression in rat
corpus cavernosum tissue. Br J Pharmacol, 134: 1190-1194, 2001.
25. ANGULO J, CUEVAS P, LA FUENTE JM, POMEROL JM, RUIZ-CASTAÑE E,
PUIGVERT A, GABANCHO S, FERNANDEZ A, NEY P, SAENZ DE TEJADA I.
Regulation of human penile smooth muscle by prostanoid receptors. Br J
Pharmacol, 136: 23-30, 2002.
26. ANGULO J, CUEVAS P, FERNÁNDEZ A, GABANCHO S, ALLONA A,
MARTÍN-MORALES A, MONCADA I, SÁENZ DE TEJADA I. Activation and
potentiation of NO/cGMP pathway by NG-hydroxy-L-arginine in rabbit corpus
cavernosum under normoxic and hypoxic conditions and ageing. Br J Pharmacol,
138: 63-70, 2003.
27. RODRIGUEZ-MAÑAS L, ANGULO J, VALLEJO S, PEIRO C, SANCHEZ-
FERRER A, CERCAS E, SANCHEZ-FERRER CF. Early and intermediate Amadori
glycosylation adducts, oxidative stress, and endothelial dysfunction in the
streptozotocin-induced diabetic rats vasculature. Diabetologia, 46: 556-566, 2003.
28. ANGULO J, BISCHOFF E, GABANCHO S, CUEVAS P, SAENZ DE TEJADA I.
Vardenafil reverses erectile dysfunction induced by paroxetine in the rat. Int J Impot
Res, 15: 90-93, 2003.
29. ANGULO J, CUEVAS P, CUEVAS B, BISCHOFF E, SAENZ DE TEJADA I.
Vardenafil enhances clitoral and vaginal blood flow responses to pelvic nerve
stimulation in female dogs. Int J Impot Res, 15: 137-141, 2003.
30. ANGULO J, CUEVAS P, FERNANDEZ A, GABANCHO S, VIDELA S, SAENZ
DE TEJADA I. Calcium dobesilate potentiates endothelium-derived hyperpolarizing
factor-mediated relaxation of human penile resistance arteries. Br J Pharmacol, 139:
854-862, 2003.
31. ANGULO J, CUEVAS P, FERNANDEZ A, GABANCHO S, ALLONA A,
MARTIN-MORALES A, MONCADA I, VIDELA S, SAENZ DE TEJADA I. Diabetes
impairs endothelium-dependent relaxation of human penile vascular tissues
mediated by NO and EDHF. Biochem Biophys Res Commun, 312: 1202-1208,
2003.
32. ANGULO J, CUEVAS P, CUEVAS B, GUPTA S, SAENZ DE TEJADA I.
Mechanisms for the inhibition of genital vascular responses by antidepressants in a
female rabbit model. J Pharmacol Exp Ther, 310: 141-149, 2004.
33. ANGULO J, CUEVAS P, GABANCHO S, GONZALEZ-CORROCHANO R,
VIDELA S, SAENZ DE TEJADA I. Enhancement of both, endothelium-derived
hyperpolarizing factor and nitric oxide/cyclic guanosin-monophosphate pathways
reverses erectile dysfunction in diabetic rats. J Sex Med, 2: 317-322, 2005.
34. GARCIA-GOMEZ I, GOLDSMITH HS, ANGULO J, PRADOS A, LOPEZ-
HERVAS P, CUEVAS B, DUHOVNY M, CUEVAS P. Angiogenic capacity of human
omental stem cells. Neurol Res, 27: 807-811, 2005.
35. ANGULO J, CUEVAS P, CUEVAS B, BISCHOFF E, SAENZ DE TEJADA I.
Vardenafil reverses antidepressant-induced inhibition of genital vascular responses
in female rabbits. J Sex Med, 3: 988-995, 2006.
36. ANGULO J, CUEVAS P, FERNÁNDEZ A, ALLONA A, MONCADA I, MARTÍN-
MORALES A, LA FUENTE JM, SAENZ DE TEJADA I. Enhanced thromboxane
receptor mediated-responses and impaired endothelium-dependent relaxation in
human corpus cavernosum from diabetic impotent men: Role of protein kinase C
activity. J Pharmacol Exp Ther, 319: 783-789, 2006.
CAPITULOS Y REVISIONES

1. ANGULO J, CUEVAS P, SAENZ DE TEJADA I. Bradykinin mediates vasoactive
effects of fibroblast growth factors. In: Cuevas P (ed). Fibroblast Growth Factor in the Cardiovascular System. I. Holzapfel Publishers, Munich, pp 67-74, 2002.
2. SAENZ DE TEJADA I, ANGULO J, CELLEK S, GONZALEZ-CADAVID N,
HEATON J, PICKARD R, SIMONSEN U. Physiology of erectile function and pathophysiology of erectile dysfunction. In: Sexual Medicine. Sexual Dysfunctions in Men and Women. Lue TF, Basson R, Rosen R, Giuliano F, Khoury S, Montorsi F (eds). Health Publications, París, pp 287-343, 2004.
3. SAENZ DE TEJADA I, ANGULO J, CELLEK S, GONZALEZ-CADAVID N,
HEATON J, PICKARD R, SIMONSEN U. Physiology of erectile function. J Sex Med, 1: 254-265, 2004.
4. SAENZ DE TEJADA I, ANGULO J, CELLEK S, GONZALEZ-CADAVID N,
HEATON J, PICKARD R, SIMONSEN U. Pathophysiology of erectile dysfunction. J Sex Med, 2: 26-39, 2005.
PONENCIAS INVITADAS EN CONGRESOS

1. ANGULO J. Mechanisms for drug-induced erectile dysfunction. 4th Congress
of the Ferderation of the European Pharmacological Societies (EPHAR) Porto, julio, 2004. 2. ANGULO J. Avances en Fisiología de la Erección. Primer Symposium
Internacional sobre Avances en Biología Molecular y Terapéutica en Urología. Bilbao, octubre, 2004. 4. ANGULO J. Male and female genital responses - Vascular function in health
and disease. 8th Congress of the European Society of Sexual Medicine. Copenhagen, December, 2005. 5. ANGULO J. Profundizando en la farmacología de los inhibidores PDE5 –
Aparición del efecto, duración, interacciones y dosificación. XIII Reunión del Grupo Uro-Andrológico. Bilbao, marzo, 2006. 6. ANGULO J. Vascular responses and sexual function. 2006 Annual Meeting
of the International Society for the Study of Women’s Sexual Health. Lisbon, March, 2006. 7. ANGULO J. Fisiologia de lo tecido endotelial. VII Reunión Ibérica de
Andrologia e Medicina Sexual y X Congresso de la Sociedade Portuguesa de Andrologia. Vidago, junio, 2006.
PREMIOS
Abbot Erectile Dysfunction Research Award 2001.
European Society for Sexual Medicine Awards: Best presentations of the 7th
Congress of the European Society for Sexual Medicine, London, diciembre 2004.
European Society for Sexual Medicine Awards: Award of Excellence 2005.

ACTIVIDAD DOCENTE
Profesor Honorario del departamento de Farmacología y Terapéutica de la Facultad
de Medicina de la Universidad Autónoma de Madrid, desde el curso 1997-98 hasta
el curso 2002-03. Colaborador Clínico Docente del departamento de Farmacología
y Terapéutica de la Facultad de Medicina de la Universidad Autónoma de Madrid,
desde el curso 2003-04.
OTROS MERITOS

Miembro del comité: Physiology, Molecular Biology of Erectile Function and
Pathophysiology of Erectile Dysfunction del 2nd International Consultation on
Erectile and Sexual Dysfunctions (2002-2003).
Miembro del Comité Científico, subcomité: Basic Science, de los 4 últimos
Congresos de la European Society for Sexual Medicine (2004, 2005, 2006, 2007).

Source: http://www.hrc.es/pdf/agenda/frutos.pdf