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Haverford.edu

Syllabus for Bio200B Winter 2005: Biomolecules and energetics
John Wagner
Kate Heston

The textbook we will use in this class is Principles of Biochemistry with a
Human Focus
by Garret and Grisham. 2002, Harcourt Publishers.
Some reading will also be assigned in the book that you used in the first quarter,
The Cell a Molecular Approach (Third ed.) by Cooper and Hausman. 2004,
ASM Press.
Required
reading
(Garret and
Grisham)

Introduction/
Chapt. 1 &
Amino acids
pp.68-81
Graphics
exercise
exploring
structure of
hemoglobin.

pp. 85-87,
bonds/primary
pp. 100-111
structure and
protein evolution.

Protein shape:
Chapter 5
secondary, tertiary
Fibrin clot
quartenary structure
formation.
and folding.
available
Proteins in action: α- pp. 127-131
Keratin and
Hemoglobin.

Proteins in action:
pp. 398-411
Hemoglobin
Fibrin clot
allostery and
analysis by
malfunction.
SDS-PAGE
Enzymes:
pp.320-342
phosphodiesterase
and Viagra.

Enzyme complexes:
pp. 723-734
DNA replication
Bioinformatic
studies of
globin
sequences

Metabolism:
Chapt. 3 &
Energetics and
Chapt. 15
Glycolysis
February
dehydrogenase
purification
and
concentration
determination

Metabolism: The
Chapt. 16
TCA cycle
set #2
available

Metabolism-electron
Chapt. 16
transport chain
LDH:
measurement
of specific
activity

Metabolism-
pp. 519--544
oxidative
C&H pp. 408- @8:30AM
phosphorylation
415 & 422-
set #2
DUE

Photosynthesis
pp. 552-570
C&H pp. 415-
417 & 422-
426

Prokaryotic gene
pp. 761-774
transcription: the lac
operon

Take home final due Thursday March 17 at 8:30 AM
Course goals and your responsibilities:
The world of biomolecules is a fascinating beehive of activity, interaction andchange. Scientists have made great strides in developing approaches to look intothis world and attempt to comprehend its order, logic and flow yet much remainsto challenge to our imagination. My goal is for each of you to become conversant the language of biomolecules through an introduction to biomolecularcomposition, form and function, with a particular focus on proteins.
I will work hard to facilitate the process of learning for us all, but remind you thatyour ability to glimpse into and understand this world is primarily in your ownhands. I urge you to engage the course material by: 1. Always attending class and coming on time.
2. Spending at least three hours of time out of class for each in class hour.
3. Staying on top of the material and with the class.
-Try to glance through the required reading, particularly the figures beforeclass.
-Take your own notes. Review them after class. Aim to identify what wasunclear to you. Be honest. One sign of a great scientist is the ability toidentify and articulate what is not clear. Believe me, this takes practice.
-Use the textbook and reading to clarify and enrich your understanding bykeeping up with the reading. Note that for exams, you will only beresponsible for material that was covered in class.
4. Using the available resources. People learn best in many different ways. Useyour faculty, the BQC, the GLG, and your fellow students by working together.
Try different strategies. Try them again and refine them to identify what worksbest for you.
The lecture portion of the class will be graded as follows:
Problem Set 1.
We can be reached at:
I will try to answer all e-mails in the evenings. If questions necessitate a moreinvolved answer, I may want set up a meeting with you.

Source: http://www.haverford.edu/biology/Wagner/PDF/Bio200S05.pdf

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