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Chapter 13: Skin The GHT Formulary applies to the treatment of adults only 13.1 Management of skin conditions
● Please refer to the BNF for information regarding vehicles, excipients, sensitisation and
suitable quantities for prescribing. 13.2 Emollient and barrier preparations How to locate a drug in Hospital 13.2.1 Emollients Emollient soap substitutes
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Emollients containing urea Emollients containing antimicrobials 13.2.1.1 Emollient bath additives Emollient bath additives with antimicrobials 13.2.2 Barrier Preparations
Cavilon® no-sting barrier film applicators 1mL & 3mL - supplied by stores not pharmacy
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Siopel ® cream - Not to be used on broken skin
Zinc and castor oil ointment – zinc preparations are restricted to use by
the dermatologists as Cavilon® and Siopel ® are the products in the Trust’s Wound Care Guidelines. 13.3 Topical local anaesthetics and antipruritics
Menthol in Aqueous cream 0.5% & 1% - are only available as ‘special’ preparations (i.e. not proprietary products). These preparations are not
cost-effective in primary care and there may be a significant delay in obtaining such preparations.
Doxepin Hydrochloride 5% cream (Xepin®) – for small areas only.
Restricted to dermatology. Doxepin cream can cause drowsiness that may affect skilled tasks and there may be a risk of sensitisation. 13.4 Topical corticosteroids
Suitable quantities of corticosteroid preparations to be prescribed for specific areas of the body
Amount per application Amount of one leg grams per
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Hydrocortisone 0.1, 0.5, 1.0 and 2.5% cream/ointment
Fluocinolone 0.0025% (Synalar 1 in 10 Dilution®) cream
Moderate
Clobetasone butyrate 0.05% (Eumovate®) cream/ointment
Betamethasone valerate 0.025% (Betnovate RD®) cream/ointment
Fludroxycortide 4 micrograms/cm2 (Haelan®) tape
Fluocinolone 0.00625% (Synalar 1 in 4 Dilution®) cream/ointment
Beclometasone dipropionate 0.025% (Propaderm®) cream/ointment
Betamethasone valerate 0.1% (Betnovate®)cream/ointment/lotion
Betamethasone dipropionate 0.05% with salicylic acid 3% (Diprosalic®) ointment
Diflucortolone 0.1% (Nerisone®) oily cream
Fluocinolone 0.025% (Synalar®) cream/ointment
Mometasone furoate 0.1% (Elocon®) cream/ointment
Very Potent
Clobetasol propionate 0.05% (Dermovate®) cream/ointment
Diflucortolone 0.3% (Nerisone Forte®) oily cream
Topical Steroids with antimicrobials
Hydrocortisone 1% and clioquinol 3% (Vioform–Hydrocortisone®) cream/ointment
Hydrocortisone 1% and clotrimazole 1% (Canesten HC®)
Hydrocortisone 1% and fusidic acid 2% (Fucidin H®) cream/ointment
Hydrocortisone 1% and miconazole 2% (Daktacort®) cream/ointment
Hydrocortisone 0.5% (cream), 1% (ointment), nystatin 100,000 units/g and chlorhexidine 1% (Nystaform HC®)
Hydrocortisone 0.5%, nystatin 100,000 units/g, benzalkonium chloride solution 0.2% and dimeticone ‘350’ 10% (Timodine®) cream
Moderate
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Clobetasone butyrate 0.05%,oxytetracycline 3% & nystatin 100,000 units/g (Trimovate®) cream
Betamethasone 0.1% and clioquinol 3% (Betnovate C®) cream/ointment
Betamethasone dipropionate 0.064% and clotrimazole 1% (Lotriderm®) cream
Betamethasone 0.1% and fusidic acid 2% (FuciBET®) cream
Betamethasone 0.1% and neomycin 0.5% (Betnovate N®) cream /ointment
Hydrocortisone butyrate 0.1% and chlorquinaldol 3% (Locoid C®) cream/ ointment
Triamcinolone 0.1% and chlortetracycline 3% (Aureocort®) ointment
Triamcinolone 0.1%, gramicidin 0.025%, neomycin 0.25%, nystatin 100,000 units/g (Tri-Adcortyl®) cream
Very Potent
Clobetasol propionate 0.05%, neomycin sulphate 0.5% and nystatin 100,000 units/g (Dermovate NN®) cream/ointment
Compound preparations
Hydrocortisone 0.25% and crotamiton 10% (Eurax-Hydrocortisone®) cream
Moderate
Hydrocortisone 1% and urea 10% (Alphaderm®) cream
Hydrocortisone 1%, urea 10%, lactic acid 5% (Calmurid HC®) cream
Steroid scalp applications
Betamethasone 0.1% (Betacap®) scalp application, (Betnovate®) scalp application, (Bettamousse®) foam scalp application
Betamethasone 0.05% and salicyclic acid 2% (Diprosalic®) scalp application
Fluocinolone acetonide 0.025% (Synalar®) gel
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Very Potent 13.5 Preparations for Eczema and Psoriasis 13.5.1 Preparations for eczema
● Please refer to section 13.2 (emollients) and 13.4 (topical corticosteroids).
Zinc paste and ichthammol bandage – only to be applied by a Nurse skilled in
● Ichthammol cream (Hospital Formula 2%) is only available as a ‘special’ preparation (i.
e. not a proprietary product). These preparations are not cost-effective in primary care and there may be a significant delay in obtaining such preparations. 13.5.2 Preparations for psoriasis Topical preparations
● Please refer to the BNF for information regarding vitamin D and analogues.
Vitamin D and analogues
Calcipotriol with betamethasone 0.05% (Dovobet®) ointment
Calcipotriol with betamethasone 0.05% (Dovobet®) gel – body and scalp
Calcitriol 3micrograms/g (Silkis®) ointment
● Treatment with Dovobet® should be initiated by a specialist and not exceed 4 weeks.
There is no experience of repeated use. Refer to BNF for dose information. Topical retinoid
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Compound product
● Chelsea Day mix (Hospital Formula) is only available as a ‘special’ preparation (i.e. not
a proprietary product). These preparations are not cost-effective in primary care and there may be a significant delay in obtaining such preparations.
Alphosyl HC® Cream (with hydrocortisone 0.5%)
Polytar® bath emollient (contains peanut oil)
● Chelsea Night mix and Coal Tar and Salicylic Acid ointments are only available as
‘special’ preparations (i.e. not proprietary products). These preparations are not cost-effective in primary care and there may be a significant delay in obtaining such preparations. Dithranol
Dithrocream® 0.1%, 0.25%, 0.5%, 1% and 2%
Dithranol in Lassar’s Paste 0.1%, 0.25%, 0.5%, 1%,
● Dithranols in Lassar’s Paste are only available as ‘special’ preparations (i.e. not
proprietary products). These preparations are not cost-effective in primary care and there may be a significant delay in obtaining such preparations. Oral retinoids for psoriasis 13.5.3 Drugs affecting the immune response
Tacrolimus 0.03% and 0.1% (Protopic®) ointment - specialist use only
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Pimecrolimus 1% cream - specialist use only
Systemic
● Please refer to section 8.2.1 for systemic preparations
13.6 Acne and rosacea 13.6.1 Topical preparations for acne Benzoyl peroxide and azelaic acid
Benzoyl peroxide aqueous gel (PanOxyl Aquagel®) 2.5%, 5%, 10%
Benzoyl peroxide aqueous/alcoholic gel (Panoxyl® ) 5%, 10%
Benzoyl peroxide 5% and clindamycin 1% (Duac® Once Daily)
Topical antibacterials for acne
Clindamycin (aqueous)(Dalacin T® lotion)
Clindamycin (aqueous/alcoholic) (Dalacin T® solution)
Erythromycin 40mg/mL and zinc acetate 12mg/mL (Zineryt®) topical solution
Topical retinoids and related preparations for acne
● Topical retinoids are contra-indicated in pregnancy. Women of childbearing age should
take adequate contraceptive precautions.
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Tretinoin cream 0.025%, gel 0.01%, 0.025%, lotion 0.025% (Retin-A®)
Isotretinoin 0.05% and erythromycin 2% gel (Isotrexin®)
13.6.2 Oral preparations for acne Oral antibacterials for acne Hormone treatment for acne Oral retinoid for acne
Isotretinoin capsules – Hospital consultant only
13.7 Preparations for warts and calluses
Salicylic acid 16.7% and lactic acid 16.7% (Salactol®) paint
Salicylic acid 12% and lactic acid 4% (Salatac®) gel
Salicylic acid 25% and podophyllum 20% (Posalfilin®) ointment
Cantharone Plus® (Cantharidin, podophyllum resin, salicylic acid) – unlicensed
Anogenital warts
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● Ideally all patients should first receive a full genito-urinary screen at GUM but there may
be circumstances when Dermatologists may need to prescribe. 13.8 Sunscreens and camouflagers 13.8.1 Sunscreen preparations
● The following sunscreens may be prescribed for skin protection against ultraviolet
radiation in abnormal cutaneous photosensitivity resulting from genetic disorders or photodermatoses, including vitiligo and those resulting from radiotherapy; chronic or recurrent herpes simplex labialis; patients taking photosensitising drugs and patients having PUVA. Photodamage 13.9 Shampoos and other preparations for scalp and hair conditions
● Please refer to the BNF for information regarding constituents.
Polytar AF® shampoo (contains peanut oil)
Polytar Plus® liquid (contains peanut oil)
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Salicylic acid and sulphur Hospital Formula scalp cream
● Salicylic acid and sulphur Hospital Formula scalp cream is only available as a ‘special’
preparation (i.e. not a proprietary product). These preparations are not cost-effective in primary care and there may be a significant delay in obtaining such preparations. 13.10 Anti-infective skin preparations 13.10.1 Antibacterial preparations 13.10.1.1 Antibacterial preparations only used topically
Polyfax® - polymixin B sulphate and bacitracin zinc ointment
Flamazine® - silver sulfadiazine 1% cream
Flammacerium ® cream (named patients) – burns patients only
● For mupirocin nasal ointment see section 12.2.3
13.10.1.2 Antibacterial preparations also used systemically
Metronidazole 0.75% cream/gel – For malodorous tumours and skin ulcers
13.10.2 Antifungal preparations
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Amorolfine 5% (Loceryl®) nail lacquer – nail infections
Tioconazole 28% (Trosyl®) nail solution – nail infections
13.10.3 Antiviral preparations
Aciclovir 5% cream - should only be started at first sign of attack. 13.10.4 Parasiticidal preparations
● Alcoholic lotions are the treatment of choice for head lice but use aqueous solutions for
patients with severe eczema or asthma.
Malathion 0.5% aqueous liquid (Derbac M®), 0.5% alcoholic lotion
Carbaryl 1% aqueous liquid, 0.5% alcoholic lotion (Carylderm®)
Phenothrin 0.5% aqueous liquid (Full Marks®)
13.10.5 Preparations for minor cuts and abrasions Skin tissue adhesive 13.11 Skin cleansers and antiseptics
● Please refer to GHNHSFT Infection Control policy
Astringents, oxidisers and dyes
Potassium permanganate (Permitabs® 400mg)
13.12 Antiperspirants
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Aluminium chloride hexahydrate 20% (Driclor®)
13.13 Wound management products and elastic hosiery
● Please refer to the GHNHSFT Wound Management Formulary
Topical treatments for scar reduction Topical treatments for malignant and pre-malignant lesions
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Eniluracil + 5-fluorouracil + leucovorin (EFL) vs. capecitabine Phase 2 trial for metastatic breast cancer (AHX-03-202) Rivera E1, Chang JC2, Semiglazov V3, Gorbunova V4, Manikhas A5, Krasnozhon D6, Kirby MG7, Spector T7 1Banner MD Anderson Cancer Center. Phoenix, AZ USA; 2The Methodist Hospital Cancer Center. Houston, TX, USA December 4‒8, 2012 3Road Clinical Hospital of
Passage en phase ambulatoire le 23 juillet 2009 En quoi la prise en charge de la grippe A/H1N1 Dois-je déclarer tous les cas suspects de grippe sera-t-elle différente à partir du 23 juillet ? Les patients ne devront plus avoir recours aux Centres 15 et aux Non, uniquement les cas groupés (3 cas en 1 semaine dans une urgences qui seront réservées aux cas compliqués, mais s’adresse-