Le sildénafil présent dans Kamagra exerce une inhibition réversible de la PDE5, modulant la cascade GMPc et favorisant une vasodilatation localisée. L’absorption digestive varie selon la forme utilisée, comprimés classiques ou gels oraux. La distribution tissulaire est large et la liaison protéique élevée, avoisinant 96 %. La métabolisation hépatique génère un métabolite actif contribuant à l’effet pharmacologique global. La demi-vie reste courte, avec disparition plasmatique en quelques heures. Les interactions significatives concernent surtout les nitrés organiques et inhibiteurs puissants du CYP3A4. Dans les publications techniques, kamagra en ligne est souvent cité dans le cadre d’analyses comparatives portant sur les différences de formulations et de cinétique d’absorption.

"annexure ii- consolidated list of unapproved list licenced by sla but not permitted by dcgi"

Fixed dose combinations – declared unapproved by Drug Controller General of India

Sl No
Name of fixed dose combinations
5 - bromosalicyl - 4 - chloranilide + Salicylic acid Aceclofenac + paracetamol + Chlorzoxazone Aceclofenac + Paracetamol + Serratiopeptidase Choline Bitartrate + Pyndoxine + Folic Acid + Vitamin E + Cyanocobalamin + Vitamin E + Cyanocobalamin + Vitamin E + Cyanocobalamin + Chromium Nicotmate + Manganese Sulfate + Zinc Sulfate" Acriflavine + Gentian violet + Brilliant green Activated charcoal + Fungal distase + Lactic acid Adenocyl Cobalamine + Carbonyl lon + Folic Acid + Zinc Ascorbate Adenocyl Cobalamine + Carbonyl Iron + Folic acid Alendronate sodium + Calcium Carbonate + Vit - D3 Alendronate sodium + Chlicalceferol f+ Calcium Citrate + Magnesium Hydroxide Allantoin + Dimethicone + Metylparaben + Propylparaben Allantoin + Triclosan + Vit - E + Zinc Oxide Allantoin + Vit - E + Cammelina Sinensis Allobarbitone + Phospho - dimethyl - isopropyl - pyrazolone Aloe extract + allantocin + Alfa tocoferal acetate + D-panthemol + Vita-A Aloe extract + Vit - E + Dimethicone + Glycerine Aloevera + Glycerine + PEG 100 stearate + Vit E Aloevera + Jojoba oil + Wheat germ oil + Tea tree oil Amoxicillin + Cloxacillin + Lactic acid bacillus Amoxicillin + Serratiopertidase + Lactobacillus Sporogenes Amoxycillin + Clavulanic acid + Lactic acid bacillus Amoxycillin + Clavulanic acid + Lactobacillus Amoxycillin + Cloxacillin + Lactic acid bacillus Amoxycillin + Cloxacillin + Lactic acid bacillus+serrapeptase Amoxycillin + Cloxacillin + Lactic acid bacillus Amoxycillin + Lactobacillus acidophilus + Clavulanic Acid Amoxycillin + Lactobacillus acidophilus + Flucloxaxcillin Sodium Ampicillin + Cloxacillin + Lactic acid bacillus Ampicillin + Flucloxacillin Sodium Salt + Lactobacillus Acidophilus Atenolol + Hydrochlorothiazide + Amilonde Atenolol + Losartan + Hydrochlorothiazide Atorvastatin + Acetyl Salicylic acid + Caffeine Atorvastatin + Mecobalamine + Folic acid Atorvastatin + Mecobalamine + Folic acid + Vit-B6 Benfotimine + Pyridoxine + Mecobalamine + Inositol + Alphalipoic acid Calcium dobesilate + Lignocaine + Hydrocortisone Cefixime + Lactic acid bacillus + Ambroxol Cefixime + Lactobacillus acidophilus + Ambroxol Cefixime + Lactobacillus + Clavulanic Acid Cefixime + Lactobacillus + Dicloxacillin Cefpodoxime + prozetil + Lactic acid bacillus Cefpodoxime + Cloxacillin + Lactobacillus Cepodoxime + Cloxacillin + Lactic acid bacillus Chlormezanone + Paracetamol + Diclofenac sodium Chlorzoxazone + Ibuprofen + Paracetamol + Diclofenac + Oxyphenbutazon +Magnesium Hydroxide Paracetamol + Diclofenac + Oxyphenbutazon Chlorzoxazone + Paracetamol + Diclofenac Potassium Chlorzoxazone + Paracetamol + Diclofenac Sodium Chlorzoxazone + Paracetamol + Ibuprofen + Diclofenac sodium Chlorzoxazone + Paracetamol + Nimesulide Ciprofloxacin + Tinidazole + Dicyclomine Clinadamycin + Clotrimazole + Metronidazole Condrortin + Vitamin + Selemum zink Sulphate + Monohydrate Diclofenac Potassium + Prtolenone hydrochlonde + Fenprvireneum bromide + Paracetamol Diclofenac + Dextropropoxyphene + Paracetamol Diclofenac + Methyl Salicylate + Lmoleic acid + Menthol Diclofenac + Paracetamol + Chlormezanone Diclofenac + Paracetamol + Dextropropoxyphene Diclofenac + Paracetamol + Serratiopeptidase Diclofenac + Paracetamol + Chlorzoxazone Diclophenac + Paracetamol + Chlormeznone Dicyclomme + Dextromethorphan + Paracetamol Dicyclomme + Diclofenac Sodium + Paracetamol Dicyclomme + Mefenamic acid + Paracetamol Dicyclomme + Paracetamol + Chlordiazepoxide Dicyclomme + Paracetamol + Clidinium Bromide Dicyclomme + Paracetamol + Clidinium Bromide + Chlordiazepoxide Dicyclomine + Paracetamol + Dextropropoxyphene Dicyclomine + Paracetamol + Dextropropoxyphene + Clordiazepoxide Dicyclomine + Paracetamol + Dimethylpolysiloxane Dicyclomine + Paracetamol + Phenylisoprophyl Pyrazolon Dicylomine + Parcetamol + Dimethylpolysiloxane Drotaverine hydrochloride + Mefenamic Acid Fenpiverinium bromide + Analgin + Pitofenone hydrochloride Fenpiverinium bromide + Diclofenac sodium + Pitofenone hydrochlonde Fenpiverinium hydroxide bromide + Diclofenac sodium + Pitofenone hydrochloride Gebapentin + Mecobalamin + Thiocitic acid Gebapentin + Mecobalamin + Thioctic acid + Folic Acid + Pyndoxine Gabapentin + Mecobalamin + Pyridoxine + Folic Acid Glucosamine + Chondroitin Sulphate + Methyl sulphonyl methane Glucosamine + Chondroitin Sulphate + Vit + C + manganise sulphate" Glucosamine + Chondroitin + Vit C + Vit E + Manganese" Glucosamine + Condroitin + Vit C + Manganese + Sodium Borate + Selinium Dioxide Glucosamine + Chondroitin + Vit - C + Vit - E + Manganese" Glucosamine + Colecalciferol + Manganese + Ascorbic acid" Glucosamine + Mecobalamin + Dimethyl Sultone Glucosamine + Mecobalamine + Milk calcium Glucosamine + Methyl sulphonyl methanamine + Cetylmystate Glucosamine + Vit C + Calcium + Methyl Sulfonyl Methane + Chondroitin + Manganese Glucosamine + Vit C + Vit E + Chondroitin sulphate + Methyl sulfonyl methane + Manganese sulphae Gluosamine sulphate + Chondroitin + Sulphate + Vit E + Manganese Hydrochlorothiazide + Ramipril + Losartan Potassium Salt Ibuprofen + Dextropropoxyphene + Paracetamol Ibuprofen + Paracetamol + Dextropropoxyphene Ibuprofen + Paracetamol + magnesium triscillicate Ibuprofen + Paracetamol + magnesium trisilicate Ibuprofen + Paracetamol + Oxyphenbutazone + Phenylisopropyl pyrazolon Ibuprofen + Paracetamol + Phenylepherine + Chlorpheniramine maleate Ibuprofen + Paracetamol + Serratiopeptidase Ibuprofen + Pseudoephedrine + Chlorpheniramine maleate Lansoprazole + Amoxycillin + Clanthromycin Lansoprazole + Tinidazole + Clanthromycin Losartan + Hydrochlorothazide + Atenotol Mecobalamin+alpoic acid + Folic acid + Vit B6+ Choline Mecobalamine + Alphalipoic acid + Folic acid Mecobalamine + Alphalipoic acid + Vit B1 + Folic acid Mecobalamine + Carotmoid + Alpha lipoic acid + Charomm + Vit B1 + Vit B Complex Mecobalamine + Vit A + Vit E + Vit C + Vit B1+ Vit B6 + Vit D3 + Selemum Mecobalamine + Vit B1 + Vit B2 + Vit B6 + Folic acid Mecobalamine + Vit B1 + Vit B6 + Folic acid + Alpha lipoic acid Mecobalamine + Vit B1 + Vit B6 + Nicotinamide + D-panthenol Mecobalamine + Vit B6 + Folic acid + Alpha lipoic acid Metoclopramide hydrochloride + Paracetamol Nimesulide + Paracetamol + Chlorsoxazone Nimesulide + Paracetamol + Serratropeptidase Nimesulide + Phenylphenne + Chlorpheniramine maleate + Caffine Nimesulide + P. Piperidinoethoxy. O + Carbomethoxybenzophenone + Diphenyl Pipendenoeteyl Norfloxacin + Tinidazole + Lactobacallus Ofloxacin + Ornidazole + Lactobacillus Sporogenes Paracetamol + Diclofenac Sodium + Amoxicillin + Cloxacillin + Pantoprazole + Lactic Acid Bacillus + Paracetamol + Diclofenac sodium + Magnesium Trisilicate + Chlorphenamine Maleate Paracetamol + Ketoprofen + Dextropropoxyphene Pregabalin + Mecobalamine + Pyridoxine + Thioctic Acid + Folic Acid Pregabalin + Thioctic Acid + Folic Acid + Pyridoxine Propranololol + Hydrochlorothiazide + Dihydrallazine Ranitidine + Dicyclomine + Clidinium bromide Telmisartan + Ramipril + Hydrochlorthazide Tizanidine + Diclofenac potassium + Acetoammophan Tizanidine + Diclofenac potassium + Paracetamol Tizanidine + Diclofenec sodium + Paracetamol
ANNEXURE V - BANNED FIXED DOSE COMBINATINS AVAILABLE IN THE COUNTRY
Name of fixed dose combinations
Fenpiverinium bromide + Analgin + Pitofenone Hydrochloride ANNEXURE IV - REJECTED FIXED DOSE COMBINATIONS BY DCGI
Name of fixed dose combinations
Etophylline + Theophyulline + Ambroxol+Gauiphenesin HCTZ+Rosuvastatin + Ramipril+Nebivolol+Folic Acid + Aspirin
* notice from Director of Drugs Control Governement of West Bengal for withdrawal

Source: http://fmrai.org/uploads/mednews/Medicine_Unapproved%20Drugs.pdf