Microsoft word - chemspeed news_sp_pd_june2013.doc

SP Process Development AB Boosts Its Catalyst Screening with
Chemspeed’s CATSCREEN 96

June 2013, SÖDERTÄLJE, Sweden / AUGST, Switzerland - "The Chemspeed CATSCREEN 96 is a real
workhorse with a capacity to run many hundreds of reactions per week. It enables us to rapidly generate and
evaluate large numbers of catalysts for important transformations such as asymmetric hydrogenations and
cross-couplings", Dr. Per Ryberg, Senior Scientist Catalysis, from SP Process Development states, "Thanks to
its unique capabilities, reliability and ease of use, the CATSCREEN 96 enables us to run entire sequences
involving: generation of catalysts from precursors, addition of substrates / reactants, reaction at up to 80 bar
pressure and sample preparation, fully automated and unattended. We use it for both catalyst screening and
reaction optimization and work that would take several weeks to do manually can be done in a few days on the
robot." Read more >>>
ChemCatChem, Volume 4, Issue 12, 2082–2089

High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of
Heteroaromatic Ketones: Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine
Elina Buitrago, Helena Lundberg, Hans Andersson, Per Ryberg, Hans Adolfsson

A total of 21 amino acid based ligands including hydroxy amide, thioamide, and hydroxamic acid functionalities, ,
were combined with [Ru(p-cymene)Cl] and [RhCp*Cl], and used as catalysts for the asymmetric transfer
hydrogenation of four different heteroaromatic ketones in 2-propanol. The reactions were performed on a
Chemspeed automated high-throughput screening robotic platform. Optimal catalysts were identified for the
individual heterocyclic substrate classes. Based on these results, the formal syntheses of the antidepressant
drugs (R)-fluoxetine and (S)-duloxetine were conducted using these optimum catalysts in the key step, which
results in high isolated yields (94 %) and excellent product enantioselectivities (>99 % ee) of the 1,3-amino
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About SP Process Development AB
SP Process Development AB, a subsidiary of SP Technical Research Institute of Sweden, applies its
internationally leading competence to the development and evaluation of technologies, material, products, and
processes to meet its customers' needs and provide an effective link between research and commercialisation
For additional information please visit
SP Process Development ● Forskargatan 18, 151 21 Södertälje, Sweden ● +46 10 516 65 00●

About Chemspeed Technologies AG
Chemspeed Technologies AG is the leading provider of high-throughput and high-output research and
development workflow solutions; from single bench-top / standalone automated workstations (powder
dispensing, sample preparation, synthesis, process development, formulation, application or testing) up to
complete and integrated product workflows for the entire product development process in the chemical, material
science, renewables & energy, pharmaceutical, agrochemical, speciality chemical, home care, cosmetics and
nutrition industries, as well as academia.
For additional information please visit
Chemspeed Technologies ● Rheinstrasse 32, 4302 Basel, Switzerland ● +41 61 816 9500 ●
Chemspeed Technologies AG • Rheinstrasse 32 • 4302 Augst • Switzerland • Phone +41 61 816 95 00 • Fax +41 61 816 95 09



The life-affirming sounds quieted. My mother stood at the foot ofthe bed, blanch-faced. My husband yelled for a doctor, any doctor. “Ohmy God, I killed my baby!” I first thought. The anesthesiologist chargedin and immediately started CPR on my baby boy—Kenny. I listened tothe murmurs that his eyes had opened and he looked around but hadshallow and ragged breath. Thank God. He was alive. Gr

Microsoft word - agosto_2007.rtf

TRIBUNAL REGIONAL ELEITORAL DE SÃO PAULO Relação Mensal de Compras: Agosto/2007 PREÇO UNIT PREÇO TOTAL FORNECEDOR CNPJ/CPF Ácido Acetilsalicílico, em cartelas com 10 comprimidos Amoxicilina + Clav Potássio, em caixas com 18 comprimidos de 500/ 125 mg, laboratório EMS. Besilato de Anlodipino, em caixas com 30 comprimidos Besilato de Anlodipino, em caixas com 30 comprimid

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