Microsoft word - chemspeed news_sp_pd_june2013.doc
SP Process Development AB Boosts Its Catalyst Screening with Chemspeed’s CATSCREEN 96 June 2013, SÖDERTÄLJE, Sweden / AUGST, Switzerland - "The Chemspeed CATSCREEN 96 is a real workhorse with a capacity to run many hundreds of reactions per week. It enables us to rapidly generate and evaluate large numbers of catalysts for important transformations such as asymmetric hydrogenations and cross-couplings", Dr. Per Ryberg, Senior Scientist Catalysis, from SP Process Development states, "Thanks to its unique capabilities, reliability and ease of use, the CATSCREEN 96 enables us to run entire sequences involving: generation of catalysts from precursors, addition of substrates / reactants, reaction at up to 80 bar pressure and sample preparation, fully automated and unattended. We use it for both catalyst screening and reaction optimization and work that would take several weeks to do manually can be done in a few days on the robot." Read more >>> http://www.sp.se/en/units/sppd/affarsomraden/Sidor/default.aspx ChemCatChem, Volume 4, Issue 12, 2082–2089
High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones: Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine Elina Buitrago, Helena Lundberg, Hans Andersson, Per Ryberg, Hans Adolfsson
A total of 21 amino acid based ligands including hydroxy amide, thioamide, and hydroxamic acid functionalities, , were combined with [Ru(p-cymene)Cl] and [RhCp*Cl], and used as catalysts for the asymmetric transfer hydrogenation of four different heteroaromatic ketones in 2-propanol. The reactions were performed on a Chemspeed automated high-throughput screening robotic platform. Optimal catalysts were identified for the individual heterocyclic substrate classes. Based on these results, the formal syntheses of the antidepressant drugs (R)-fluoxetine and (S)-duloxetine were conducted using these optimum catalysts in the key step, which results in high isolated yields (94 %) and excellent product enantioselectivities (>99 % ee) of the 1,3-amino alcohols. See the full article under: http://onlinelibrary.wiley.com/doi/10.1002/cctc.201200308/abstract
About SP Process Development AB SP Process Development AB, a subsidiary of SP Technical Research Institute of Sweden, applies its internationally leading competence to the development and evaluation of technologies, material, products, and processes to meet its customers' needs and provide an effective link between research and commercialisation
For additional information please visit www.sp.se/en/units/sppd/Sidor/default.aspx
SP Process Development ● Forskargatan 18, 151 21 Södertälje, Sweden ● +46 10 516 65 00●
info@sp.se
About Chemspeed Technologies AG Chemspeed Technologies AG is the leading provider of high-throughput and high-output research and development workflow solutions; from single bench-top / standalone automated workstations (powder dispensing, sample preparation, synthesis, process development, formulation, application or testing) up to complete and integrated product workflows for the entire product development process in the chemical, material science, renewables & energy, pharmaceutical, agrochemical, speciality chemical, home care, cosmetics and nutrition industries, as well as academia.
For additional information please visit www.chemspeed.com
Chemspeed Technologies ● Rheinstrasse 32, 4302 Basel, Switzerland ● +41 61 816 9500 ●
chemspeed@chemspeed.com Chemspeed Technologies AG • Rheinstrasse 32 • 4302 Augst • Switzerland • Phone +41 61 816 95 00 • Fax +41 61 816 95 09
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TRIBUNAL REGIONAL ELEITORAL DE SÃO PAULO Relação Mensal de Compras: Agosto/2007 PREÇO UNIT PREÇO TOTAL FORNECEDOR CNPJ/CPF Ácido Acetilsalicílico, em cartelas com 10 comprimidos Amoxicilina + Clav Potássio, em caixas com 18 comprimidos de 500/ 125 mg, laboratório EMS. Besilato de Anlodipino, em caixas com 30 comprimidos Besilato de Anlodipino, em caixas com 30 comprimid