Appendix 10: Carcinogens
The list below is a compilation of substances classified as carcinogens by either the
International Agency for Research on Cancer (IARC) and the National Toxicology Program
(NTP). Some of these substances are classified as “Select Carcinogens” and require special
work practices. See Appendix 1 for the definition of “Select Carcinogen”
Chemical Name
AF-2 (2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide)
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
Analgesic mixtures containing phenacetin
Chemical Name
N,N-Bis(2-chloroethyl)-2-naphthylamine (chlornaphazine)
Bis(chloromethyl)ether (technical grade)
1,4-Butanediol dimethanesulfonate (Busulphan Myleran)
Chlorinated paraffins (C12 60% Chlorine)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
Chloromethyl methyl ether (technical-grade)
p-Choro-o-toluidine and its strong acid salts
Chemical Name
Dantron (Chrysazin; 1, 8-Dihydroxyanthraquinone)
3,3'-Dichloro-4-4'-diaminodiphenyl ether
Chemical Name
Trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-
Estrogens (not conjugated) estradiol-17ß
Estrogens (not conjugated) ethinylestradiol
Etoposide in combination with cisplatin and bleomycin
2-(2-Formylhydrazino)-4-(5-(5-nitro-2-furyl)thiazole
Glu-P-1 (2-amino-6-methyldipyrido[1, 2-a:3', 2'-d]imidazole)
Glu-P-2 (2-aminodipyrido[1, 2-a:3',2'-d]imidazole)
Chemical Name
Inorganic-acid mists, containing sulfuric acid
IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)
MeA-a-C (2-Amino-3-methyl-9H-pyrido[2, 3]indole)
MelQ (2-Amino-3, 4-dimethylimidazol[4, 5f]quinoline
MelQx (2-AMino-3, 8-dimethylimidazo[4, 5-f]quinoxaline
8-Methoxysoralen (methoxsalen) plus ultraviolet A radiation
4,4'-Methylene bis(2-chloroaniline) (MBOCA)
4,4'-Methylene bis(N,N-dimethylbenzenamine)
2-Methyl-1-nitroanthraquinone (uncertain purity)
N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG)
Michler's ketone [4,4’-(Dimethylamino)benzophenone]
Mineral oils, untreated and mildly-treated
MOPP and other combined chemotherapy including
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2-
Chemical Name
1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
N-[4-(5-Nitro-2-furyl)-2-thiaxolyl]acetamide
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-butanone (NNK)
Oestrogen-progestogen therapy, post menopausal
Palygorskite (long fibers, > 5 micrometers)
Panfuran S (containing dihydorxymethylfuratrizine)
Chemical Name
Phlp (2-Amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine)
Silica, crystalline cristobalite (respirable size)
Silica, crystalline tridymite (respirable size)
Silica, crystalline quartz (respirable size)
Strong inorganic acid mists containing sulfuric acid
2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD)
Chemical Name
Trichlormethine (trimustine hydrochloride)
Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b] indole)
Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)
(a) International Agency for Research on Cancer (IARC):
1. Carcinogenic to humans with sufficient epidemiological evidence 2A. Probably carcinogenic to humans with (usually) at least limited human evidence 2B. Probably carcinogenic to humans, but having (usually) no human evidence
For a complete listing of IARC carcinogens, mixtures and exposure circumstances, see http://www.iarc.fr
a. Known to be carcinogenic with evidence from human studies b. Reasonably anticipated to be a carcinogen, with limited evidence in humans or sufficient evidence in experimental animals
More information on NTP carcinogens can be found at: http://ntp-server.niehs.nih.gov
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