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HALF-LIFE AND TIME TO STEADY STATE (T to SS)
CLS Lab References1,2
MicroMedex5
Lexicomp6
Goodman &
CHR Pharmacy
Services8
Half-Life
Half-Life
Half Life
Half-Life
Half-Life
Half Life
95 h (obese adults ) 37-169 h (elderly) 22-54 h (neonates) M:\Manuals\Chemistry\Active\Shared_Attachments\Half-Life and Time to Steady State-20091120.doc HALF-LIFE AND TIME TO STEADY STATE (T to SS)
CLS Lab References1,2
MicroMedex
Lexicomp6
Goodman &
CHR Pharmacy
Services8
Half-Life T to SS
Half-Life
Half Life
Half-Life
Half-Life
Half Life
18-25 h (infant) 35 h (child) 38-48 h (adult) dysfunction) 3-11.5 h (neonate & infant) M:\Manuals\Chemistry\Active\Shared_Attachments\Half-Life and Time to Steady State-20091120.doc HALF-LIFE AND TIME TO STEADY STATE (T to SS)
CLS Lab References1,2
MicroMedex5
Lexicomp6
Goodman &
CHR Pharmacy
Services8
Half-Life
Half-Life
Half Life
Half-Life
Half-Life
Half Life
M:\Manuals\Chemistry\Active\Shared_Attachments\Half-Life and Time to Steady State-20091120.doc HALF-LIFE AND TIME TO STEADY STATE (T to SS)
CLS Lab References1,2
MicroMedex5
Lexicomp6
Goodman &
CHR Pharmacy
Services8
Half-Life
Half-Life
Half Life
Half-Life
Half-Life
Half Life
xCalculation (Half-life x 5 = time to steady state) *Based on information found in more than one reference TBA = to be determined after next revision. M:\Manuals\Chemistry\Active\Shared_Attachments\Half-Life and Time to Steady State-20091120.doc HALF-LIFE AND TIME TO STEADY STATE (T to SS)
Disposition of Toxic Drugs and Chemicals in Man (7thEd.) Foster City, CA: Biomedical Publications, 2004. 2) Alan Wu. Tietz Clinical Guide to Laboratory Tests (4th Ed.) Elsevier, 2006. 3) Compedium of Pharmaceutical Sciences (CPS) [electronic version]. Canadian Pharmacists Association, 2006. (cited: 07/2007). 4) AHFS Drug Information [database online]. McEvoy GK, ed. Bethesda, MD: American Society of Health-System Pharmacists; 2006. (cited: 07/2007). 5) Micromedex ® Healthcare Series, (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: 6) Lacy CF, Armstrong LL, Goldman MP, Lance LL. Drug Information Handbook International: A Comprehensive Resource for all Clinicians and Healthcare Professionals, (14th Ed.) Husdon, OH: Lexicomp Inc. 2006. 7) Brunton LL, ed. Goodman & Gilman’s The Pharmacological Basis of Therapeutics (11th Ed.) Mcgraw-Hill Medical Publishing Division 2006. 8) Drug Information Pharmacists, CHR, Pharmacy Services, 2007. 9) Tietz Clinical Guide to Laboratory Tests (4th Edition), Edited by Alan Wu, 2006, W.B. Saunders Company. 10) Bleyer WA. The clinical pharmacology of methotrexate: new applications for an old drug. Cancer 1978, 41:36-51. M:\Manuals\Chemistry\Active\Shared_Attachments\Half-Life and Time to Steady State-20091120.doc

Source: http://www.calgarylabservices.com/files/labtests/halflifetime.pdf

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United States Court of Appeals For the First Circuit MARÍA YOLANDA MARCANO RIVERA; JORGE RODRÍGUEZ MATOS;HOSPITAL INTERAMERICANO DE MEDECINA AVANZADA,APPEAL FROM THE UNITED STATES DISTRICT COURT[Hon. Héctor M. Laffitte, U.S. District Judge] Lynch, Lipez, and Howard, Circuit Judges. Orlando H. Martínez-Echeverría, with whom Fernando E. AgraitJorge M. Suro Ballester, with whom Carlo

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